{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T02:21:04Z","timestamp":1720146064668},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T00:00:00Z","timestamp":1503532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005218","name":"National Center for Preparedness, Detection, and Control of Infectious Diseases","doi-asserted-by":"publisher","award":["MOHW105\u2010TDU\u2010 M\u2010212\u2010000006","MOHW104\u2010CDC\u2010C\u2010114\u2010114901"],"award-info":[{"award-number":["MOHW105\u2010TDU\u2010 M\u2010212\u2010000006","MOHW104\u2010CDC\u2010C\u2010114\u2010114901"]}],"id":[{"id":"10.13039\/100005218","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Southern Taiwan experienced a severe dengue epidemic in 2015. Adult asymptomatic cases would raise concerns on transfusion\u2010transmitted dengue virus (DENV) infection. The aim of this study was to evaluate the magnitude of such a risk in Tainan City during this epidemic.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>The daily prevalence of asymptomatic dengue viremia in blood donors in Tainan City and in selected high\u2010incidence districts during the 2015 dengue epidemic was estimated by an established mathematical model. Duration of viremia, duration of viremia before symptom onset, apparent\u2010to\u2010inapparent infection ratio, and reporting\u2010to\u2010underreporting ratio were four main parameters used in the model.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The estimated maximal and mean daily prevalence of asymptomatic dengue viremia in blood donors in Tainan during this dengue epidemic was 74.4 (95% confidence interval [CI], 60.8\u201088.0) and 15.0 (95% CI, 12.3\u201017.7) per 10,000, respectively. In the district with the highest incidence, the maximal and mean daily prevalence of asymptomatic viremia was 328.8 (95% CI, 271.1\u2010386.2) and 55.3 (95% CI, 43.4\u201063.3) per 10,000, respectively. Approximately 234 (95% CI, 191\u2010276) blood components containing DENV were produced during the epidemic.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Although dengue is currently not endemic in Taiwan, physicians need to be aware of the risk of transfusion\u2010transmitted DENV infection. Our results suggest that screening measures to ensure blood safety should be evaluated and implemented during dengue epidemics even in nonendemic areas. Timely estimation of daily asymptomatic viremia prevalence by districts can help to select high\u2010risk areas for such measures and to evaluate cost\u2010effectiveness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14281","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T04:07:47Z","timestamp":1503634067000},"page":"2649-2656","source":"Crossref","is-referenced-by-count":9,"title":["High estimated prevalence of asymptomatic dengue viremia in blood donors during a dengue epidemic in southern Taiwan, 2015"],"prefix":"10.1111","volume":"57","author":[{"given":"Yu\u2010Wen","family":"Chien","sequence":"first","affiliation":[{"name":"Department of Public Health College of Medicine, National Cheng Kung University Tainan"},{"name":"Department of Occupational and Environmental Medicine National Cheng Kung University Hospital Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Chen","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Mathematics National Cheng Kung University Tainan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun\u2010Ta","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Information Engineering National Cheng Kung University Tainan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Yin","family":"Yeh","sequence":"additional","affiliation":[{"name":"Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University Tainan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Chien","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Medicine College of Medicine, National Cheng Kung University Tainan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nai\u2010Ying","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Nursing College of Medicine, National Cheng Kung University Tainan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guey\u2010Chuen","family":"Perng","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology College of Medicine, National Cheng Kung University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,24]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Global strategy for dengue prevention and control 2012\u20102020. 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