{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:31:48Z","timestamp":1781850708342,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T00:00:00Z","timestamp":1504656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Because there is a global shortage of intravenous immunoglobulin, there is a need for new products to fill the gap.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>This was a multicenter, open\u2010label study investigating the safety and efficacy of a newly developed mini\u2010pool intravenous immunoglobulin G for children with immune thrombocytopenia. Seventy\u2010two patients ages 1 to 18 years with newly diagnosed (&lt;1 month) immune thrombocytopenia who had platelet counts from 5 to 20 \u00d7 10<jats:sup>9<\/jats:sup>\/L with no serious bleeding were recruited from four centers in Egypt. Eligible patients were randomized into three groups 1:1:1. Group A (n\u2009=\u200924) received blood group\u2013specific mini\u2010pool intravenous immunoglobulin in a dose equivalent to immunoglobulin 1 g\/kg over 6 to 8 hours, Group B (n\u2009=\u200924) received standard intravenous immunoglobulin (approximately 1g\/kg) as a single dose, and Group C (n\u2009=\u200924) did not receive any platelet\u2010enhancing therapy. Parents signed informed consent.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Of the patients who received mini\u2010pool intravenous immunoglobulin, 14 achieved a complete response (CR) (58.8%), and four had a response (16.6%). Of the patients who received intravenous immunoglobulin G, 16 achieved a complete response (66.6%), and four had a response (16.6%). In Group C, eight patients achieved a complete response (33.3%), and four had a response (16.6%). The median time to response was 8, 9, and 21 days in Group A, B, and C, respectively, which was significantly higher in Group C than Groups A and B (p\u2009&lt;\u20090.001). Patients in Groups A and B reported 16 adverse drug reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Mini\u2010pool intravenous immunoglobulin G was well tolerated, presented no safety issues, and was effective in the treatment of immune thrombocytopenia, with efficacy comparable to that of the standard intravenous immunoglobulin G group, and it was significantly more effective than no treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14301","type":"journal-article","created":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T13:16:48Z","timestamp":1504790208000},"page":"3019-3025","source":"Crossref","is-referenced-by-count":16,"title":["A randomized multicenter study: safety and efficacy of mini\u2010pool intravenous immunoglobulin versus standard immunoglobulin in children aged 1\u201018 years with immune thrombocytopenia"],"prefix":"10.1111","volume":"57","author":[{"given":"Mohsen","family":"Elalfy","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology Ain Shams University Hospitals, National Research Center Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa","family":"Reda","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Ain Shams University Hospitals, National Research Center Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Islam","family":"Elghamry","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Ain Shams University Hospitals, National Research Center Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Elalfy","sequence":"additional","affiliation":[{"name":"Complementary Medicine Department National Research Center Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Meabed","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Beni\u2010Suef University Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"El\u2010Ekiaby","sequence":"additional","affiliation":[{"name":"School of Medicine Health Sciences Research Department, New Giza University Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud A.","family":"El\u2010Hawy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Menoufia University Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Goubran","sequence":"additional","affiliation":[{"name":"University of Saskatchewan Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdy","family":"El\u2010Ekiaby","sequence":"additional","affiliation":[{"name":"Hematology Unit, Blood Transfusion Center, Shabrawishi Hospital Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00629"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2011.06.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2016.03.018"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-162503"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000089465"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2014.10.004"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000442769"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2015.1104671"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13090"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13116"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12198"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21007"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24358"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12897"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biologicals.2014.04.002"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003501"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-013-2254-6"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25961"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-010-0950-0"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-302984"},{"key":"e_1_2_8_22_1","first-page":"340","article-title":"Efficacy of combined intravenous immunoglobulins and steroids in children with primary immune thrombocytopenia and persistent bleeding symptoms","volume":"12","author":"Parodi E","year":"2014","journal-title":"Blood Transfus"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-215525"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000262293"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07743.x"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.14301","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.14301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T05:52:59Z","timestamp":1694757179000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.14301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,6]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/trf.14301"],"URL":"https:\/\/doi.org\/10.1111\/trf.14301","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,6]]}}}