{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T15:38:07Z","timestamp":1711121887122},"reference-count":7,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The transmission of pathogens, antibodies, and proteins is a possible consequence of blood product transfusion. A female patient had an unexpected positive serum \u03b2\u2010human chorionic gonadotropin result, indicative of pregnancy, after she had received a transfusion with 1 unit of platelet concentrate, 4 units of red blood cells, and 4 units of pooled solvent\/detergent\u2010treated plasma (Octaplas).<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>To investigate the possibility of passive transfusion of \u03b2\u2010human chorionic gonadotropin from the plasma transfusion, one additional unit from the same batch was thawed and analyzed. To validate the \u03b2\u2010human chorionic gonadotropin assay for use in solvent\/detergent\u2010treated plasma and to investigate any interference in the assay, dilution experiments were performed using the implicated plasma batch diluted with male and non\u2010pregnant female sera. Also, plasma from a known pregnant woman was diluted with Octaplas (tested negative for \u03b2\u2010human chorionic gonadotropin) and with a male serum to validate the assay for use in solvent\/detergent\u2010treated plasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The implicated solvent\/detergent\u2010treated plasma had a mean \u03b2\u2010human chorionic gonadotropin level of 91.5 mIU\/mL. Results from the dilution experiments revealed an excellent correlation (r\u2009&gt;\u20090.99) between \u03b2\u2010human chorionic gonadotropin measurement in solvent\/detergent\u2010treated plasma and male serum and no over or under recovery of the expected results. Further measurements of \u03b2\u2010human chorionic gonadotropin levels in the female recipient revealed an estimated half\u2010life of 6 hours.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>This case demonstrates the importance of considering the possibility of passive transmission of analytes to a patient from the transfusion of blood products. Furthermore, the measurement of \u03b2\u2010human chorionic gonadotropin is valid in solvent\/detergent\u2010treated plasma using a Roche Cobas analyzer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14304","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T07:19:22Z","timestamp":1505373562000},"page":"2965-2968","source":"Crossref","is-referenced-by-count":2,"title":["False\u2010positive pregnancy test after transfusion of solvent\/detergent\u2010treated plasma"],"prefix":"10.1111","volume":"57","author":[{"given":"Petra","family":"Jilma\u2010Stohlawetz","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Division of Medical and Chemical Laboratory Diagnostics Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Wreford\u2010Bush","sequence":"additional","affiliation":[{"name":"Blood Transfusion Laboratory, Pathology Sciences, Southmead Hospital Bristol United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Mills","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry, Pathology Sciences, Southmead Hospital Bristol United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Davidson","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry, Pathology Sciences, Southmead Hospital Bristol United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich W.","family":"Kursten","sequence":"additional","affiliation":[{"name":"Clinical Research and Development Department Octapharma Pharmazeutika Produktionsges m.b.H Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Jilma","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Birchall","sequence":"additional","affiliation":[{"name":"Blood Transfusion Laboratory, Pathology Sciences, Southmead Hospital Bristol United Kingdom"},{"name":"National Health Service Blood &amp; Transplant Filton United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2012.09167.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.9.2480.2480"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.04320.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.2002.00222.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1989.tb04952.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01191.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-28-12-1712"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.14304","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.14304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T05:52:20Z","timestamp":1694757140000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.14304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,14]]},"references-count":7,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/trf.14304"],"URL":"https:\/\/doi.org\/10.1111\/trf.14304","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,14]]}}}