{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:18:55Z","timestamp":1788347935201,"version":"build-2803163510"},"reference-count":11,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T00:00:00Z","timestamp":1504828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Directed donation is associated with a higher prevalence of donations that are positive for infectious disease markers; however, little is known about the positive rates among parental\u2010directed, non\u2010parental\u2013directed, and allogeneic donations.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>We reviewed blood\u2010collection records from January 1997 through December 2008, including infectious disease results, among parental, non\u2010parental, and community donations. Infectious disease rates were compared by Mann\u2010Whitney U test.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In total, 1532 parental, 4910 non\u2010parental, and 17,423 community donations were examined. Among parental donors, the median rate of positive infectious disease testing was 8.66% (interquartile range (IQR), 4.49%) for first\u2010time donors and 1.26% (IQR, 5.86%) for repeat donors; among non\u2010parental donors, the rate was 1.09% (IQR, 0.98%) for first\u2010time donors and 0% (IQR, 0.83%) for repeat donors; and, among community donors, the rate was 2.95% (IQR, 1.50%) for first\u2010time donors and 0.45% (IQR, 0.82%) for repeat donors. The mean rate of positive infectious disease testing for first\u2010time parental donors was significantly higher (7.63%), whereas all repeat donors had similar rates. However, the rate of positive infectious disease testing among first\u2010time non\u2010parental donors was significantly lower than that in the other groups, especially for the period from 2001 through 2008.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>First\u2010time non\u2010parental and community donors had significantly higher infectious disease risk than the respective repeat donors. First\u2010time parental donors had the highest rates of positive infectious disease testing. We suggest that first\u2010time parental blood donation should be discouraged. Repeat community donors or first\u2010time non\u2010parental donors provide a safer alternative. These findings can foster better patient education, donor selection, and possibly a reduced risk of infectious disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14312","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T11:24:26Z","timestamp":1504869866000},"page":"2799-2803","source":"Crossref","is-referenced-by-count":10,"title":["Parental versus non\u2010parental\u2013directed donation: an 11\u2010year experience of infectious disease testing at a pediatric tertiary care blood donor center"],"prefix":"10.1111","volume":"57","author":[{"given":"Cyril","family":"Jacquot","sequence":"first","affiliation":[{"name":"Divisions of Laboratory Medicine and Hematology Center for Cancer and Blood Disorders, Sheikh Zayed Campus for Advanced Children's Medicine, Children's National Health System Washington DC"},{"name":"Department of Pediatrics George Washington University School of Medicine and Health Sciences Washington DC"},{"name":"Department of Pathology George Washington University School of Medicine and Health Sciences Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Seo","sequence":"additional","affiliation":[{"name":"Divisions of Laboratory Medicine and Hematology Center for Cancer and Blood Disorders, Sheikh Zayed Campus for Advanced Children's Medicine, Children's National Health System Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Miller","sequence":"additional","affiliation":[{"name":"Divisions of Laboratory Medicine and Hematology Center for Cancer and Blood Disorders, Sheikh Zayed Campus for Advanced Children's Medicine, Children's National Health System Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niara","family":"Lezama","sequence":"additional","affiliation":[{"name":"Divisions of Laboratory Medicine and Hematology Center for Cancer and Blood Disorders, Sheikh Zayed Campus for Advanced Children's Medicine, Children's National Health System Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valli R.","family":"Criss","sequence":"additional","affiliation":[{"name":"Divisions of Laboratory Medicine and Hematology Center for Cancer and Blood Disorders, Sheikh Zayed Campus for Advanced Children's Medicine, Children's National Health System Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Colvin","sequence":"additional","affiliation":[{"name":"Divisions of Laboratory Medicine and Hematology Center for Cancer and Blood Disorders, Sheikh Zayed Campus for Advanced Children's Medicine, Children's National Health System Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi L.C.","family":"Luban","sequence":"additional","affiliation":[{"name":"Divisions of Laboratory Medicine and Hematology Center for Cancer and Blood Disorders, Sheikh Zayed Campus for Advanced Children's Medicine, Children's National Health System Washington DC"},{"name":"Department of Pediatrics George Washington University School of Medicine and Health Sciences Washington DC"},{"name":"Department of Pathology George Washington University School of Medicine and Health Sciences Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward C.C.","family":"Wong","sequence":"additional","affiliation":[{"name":"Divisions of Laboratory Medicine and Hematology Center for Cancer and Blood Disorders, Sheikh Zayed Campus for Advanced Children's Medicine, Children's National Health System Washington DC"},{"name":"Department of Pediatrics George Washington University School of Medicine and Health Sciences Washington DC"},{"name":"Department of Pathology George Washington University School of Medicine and Health Sciences Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03904.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1989.29189101167.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1989.29121504283.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.22945"},{"key":"e_1_2_7_6_1","first-page":"159","article-title":"The degree of safety of family replacement donors versus voluntary non\u2010remunerated donors in an Egyptian population: a comparative study","volume":"12","author":"Abdel Messih IY","year":"2014","journal-title":"Blood Transfus"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4314\/pamj.v9i1.71219"},{"key":"e_1_2_7_8_1","first-page":"45","article-title":"Seroprevalence of transfusion transmissible infections among blood donors in a tertiary care hospital of Andhra Pradesh","volume":"2","author":"Bhawani Y","year":"2010","journal-title":"Biol Med"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-8-96"},{"key":"e_1_2_7_10_1","first-page":"24","article-title":"Seroprevalence of HBV, HCV and HIV infection among voluntary non\u2010remunerated and replacement donors in northern Pakistan","volume":"20","author":"Asif N","year":"2004","journal-title":"Pak J Med Sci"},{"key":"e_1_2_7_11_1","first-page":"10","article-title":"Directed blood donations: a matter of public trust","volume":"17","author":"Salonen K.","year":"1996","journal-title":"Health Law Can"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02622.x"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.14312","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.14312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:45:02Z","timestamp":1695491102000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.14312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,8]]},"references-count":11,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/trf.14312"],"URL":"https:\/\/doi.org\/10.1111\/trf.14312","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,8]]}}}