{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T15:29:46Z","timestamp":1781191786752,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T00:00:00Z","timestamp":1508976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>An 8\u2010month\u2010old recipient of a liver segment transplant had anti\u2010D detected for the first time in her Day\u00a05 posttransplant plasma and anti\u2010C detected for the first time in her Day\u00a055 posttransplant plasma. The donor's plasma contained anti\u2010C and anti\u2010D. Clinical and laboratory findings established a diagnosis of passenger lymphocyte syndrome (PLS). Hemolysis did not occur, because the recipient's blood group phenotype was, by chance, D\u2013 C\u2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>To evaluate contemporary practice for diagnosing PLS, we conducted a retrospective 10\u2010year literature review.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>There were 31 studies (63 cases) of PLS of which eight cases (four studies) were hematopoietic stem cell and 55 (27 studies) were organ transplants. All eight (100%) hematopoietic stem cell and 52 (95%) organ transplants were associated with hemolysis. Of the four studies of hematopoietic stem cell PLS, three actively screened for posttransplant blood group antibodies. Of 27 studies of organ PLS, one actively screened for antibodies. Antibody screens detected five cases of hematopoietic stem cell PLS before hemolysis was apparent and two cases of organ PLS with antibodies without hemolysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Focusing on hemolysis, without a comparable effort to detect donor\u2010derived antibodies diverts from the primary pathophysiology of PLS and limits capturing the full scope of the syndrome. Recognition of hemolytic and nonhemolytic subcategories of PLS is recommended. When feasible, an antibody screen performed on the donor's plasma when collecting the hematopoietic stem cells or before an organ harvest could result in an alert that the donor has formed an alloantibody(s) and the recipient is a risk for PLS. Alternatively, a routine antibody screen performed on the recipient's plasma 1 week posttransplant and, if negative, repeated 3 to 5 weeks posttransplant would detect any donor\u2010derived antibodies and improve alignment of clinical practice with the pathophysiology of PLS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14383","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T04:12:45Z","timestamp":1509077565000},"page":"2942-2945","source":"Crossref","is-referenced-by-count":10,"title":["Nonhemolytic passenger lymphocyte syndrome"],"prefix":"10.1111","volume":"57","author":[{"given":"S. Gerald","family":"Sandler","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, and the Transplant Institute MedStar Georgetown University Hospital Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhua","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, and the Transplant Institute MedStar Georgetown University Hospital Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Langeberg","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, and the Transplant Institute MedStar Georgetown University Hospital Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cal","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, and the Transplant Institute MedStar Georgetown University Hospital 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