{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:19:04Z","timestamp":1793780344651,"version":"4.6.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The risks and benefits of red blood cell (RBC) transfusion in palliative care patients remain poorly understood. We reviewed the literature to summarize available information on RBC transfusion in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>We searched electronic databases (MEDLINE, Embase, PsycINFO, CINAHL) from inception through September 2016 to identify studies reporting data on palliative patients receiving RBC transfusion. Original studies that assessed RBC transfusion as an intervention and reported at least one clinical outcome were included. Study characteristics, results on transfusion\u2010related outcomes, and authors' conclusions on the value of transfusion in palliative patients were abstracted and reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>We identified 1839 studies, of which 137 were selected for data extraction and 13 were included (11 case series, one prospective cohort, and one retrospective cohort). Nine studies addressed symptom relief following transfusion using subjective symptom scales, of which eight (89%) indicated some degree of short\u2010term benefit and one study (11%) showed no benefit. Posttransfusion survival was reported in four studies\u2014one demonstrated prolonged survival in patients receiving RBC transfusion; three had no comparison group. Other outcomes reported included hemoglobin values posttransfusion in four studies and adverse events following transfusion in three studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In palliative care, RBC transfusion may provide symptom relief and improve subjective well\u2010being, though the duration and magnitude of this effect, and transfusion\u2010associated risks specific to this population remain unclear. Currently, no high quality evidence exists to support or guide the use of RBC transfusion in this population. Moreover, the clinical heterogeneity within the palliative population limits the interpretation of most studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14413","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T19:45:45Z","timestamp":1512157545000},"page":"233-241","source":"Crossref","is-referenced-by-count":41,"title":["Red blood cell transfusion in adult palliative care: a systematic review"],"prefix":"10.1111","volume":"58","author":[{"given":"Nicolas","family":"Chin\u2010Yee","sequence":"first","affiliation":[{"name":"Department of Medicine University of Ottawa\/The Ottawa Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Taylor","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital Research Institute Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"Rourke","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital Research Institute Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danika","family":"Faig","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital Research Institute Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Ottawa\/The Ottawa Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Fergusson","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital Research Institute Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elianna","family":"Saidenberg","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Ottawa\/The Ottawa Hospital"},{"name":"The Ottawa Hospital Research Institute Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"WHO definition of palliative care [Internet]. 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