{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:10:48Z","timestamp":1760346648176,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T00:00:00Z","timestamp":1511913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Intravenous immunoglobulin (IVIG) has known efficacy in various hematologic conditions, including immune thrombocytopenic purpura.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>We present the clinical course of a patient with splenic marginal zone lymphoma, who developed acute thrombocytopenia on three consecutive episodes, with nadir counts of 27 \u00d7 10<jats:sup>9<\/jats:sup>, 50 \u00d7 10<jats:sup>9<\/jats:sup>, and 9 \u00d7 10<jats:sup>9<\/jats:sup>\/L, upon administration of Intratect IVIG for hypogammaglobulinemia. An immunofluorescence test applying flow cytometry and monoclonal antibody immobilization of platelet antigens (MAIPA) assay were used to evaluate the reaction between IgG present in the IVIG preparations and the patient's or healthy donors' platelets (PLTs).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A strong direct binding reaction was observed between the patient's PLTs and Intratect IgG using both methods. A similar reaction failed to materialize with controls. Binding was not antigen specific according to MAIPA.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>This is the first reported case of thrombocytopenia as a possible adverse effect of IVIG.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14419","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T17:46:44Z","timestamp":1511977604000},"page":"493-497","source":"Crossref","is-referenced-by-count":6,"title":["Intravenous immunoglobulin\u2013induced acute thrombocytopenia"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9698-1306","authenticated-orcid":false,"given":"Anna","family":"Gurevich\u2010Shapiro","sequence":"first","affiliation":[{"name":"Internal Medicine H Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Institute of Hematology, Davidoff Cancer Center, Beilinson Hospital Rabin Medical Center Petah\u2010Tiqwa Israel"},{"name":"Sackler School of Medicine Tel Aviv University Ramat\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilach","family":"Bonstein","sequence":"additional","affiliation":[{"name":"Platelet Immunology Laboratory Rambam Medical Center Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galia","family":"Spectre","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Davidoff Cancer Center, Beilinson Hospital Rabin Medical Center Petah\u2010Tiqwa Israel"},{"name":"Sackler School of Medicine Tel Aviv University Ramat\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nardeen","family":"Atweh","sequence":"additional","affiliation":[{"name":"Platelet Immunology Laboratory Rambam Medical Center Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsipora","family":"Gruenewal","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Davidoff Cancer Center, Beilinson Hospital Rabin Medical Center Petah\u2010Tiqwa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel Aviv University Ramat\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boaz","family":"Tadmor","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Davidoff Cancer Center, Beilinson Hospital Rabin Medical Center Petah\u2010Tiqwa Israel"},{"name":"Sackler School of Medicine Tel Aviv University Ramat\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pia","family":"Raanani","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Davidoff Cancer Center, Beilinson Hospital Rabin Medical Center Petah\u2010Tiqwa Israel"},{"name":"Sackler School of Medicine Tel Aviv University Ramat\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-10-10"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/11537660-000000000-00000"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2011.11.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-3002-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.117101"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.08.033"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00011"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-200311000-00009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2011.07.024"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-021568"},{"key":"e_1_2_8_12_1","first-page":"178A","article-title":"Intravascular hemolysis from liquid IVIG may be caused by anti A, B antibody","volume":"52","author":"Alhumaidan H","year":"2012","journal-title":"Transfusion"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70300-X"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23503"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-016-3016-y"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V70.6.1722.1722"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1182\/asheducation.V2012.1.306.3798320","article-title":"Pathogenesis in immune thrombocytopenia: new insights","volume":"2012","author":"Johnsen J.","year":"2012","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"e_1_2_8_18_1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1182\/blood.V53.4.545.545","article-title":"Immune thrombocytopenia in lymphoproliferative diseases","volume":"53","author":"Kaden BR","year":"1979","journal-title":"Blood"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13105"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13097"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21372"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.14419","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.14419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:55:22Z","timestamp":1695495322000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.14419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,29]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/trf.14419"],"URL":"https:\/\/doi.org\/10.1111\/trf.14419","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"type":"print","value":"0041-1132"},{"type":"electronic","value":"1537-2995"}],"subject":[],"published":{"date-parts":[[2017,11,29]]}}}