{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:20:30Z","timestamp":1787016030395,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T00:00:00Z","timestamp":1513123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>This Phase 3 randomized, double\u2010blind study evaluated the efficacy and safety of plerixafor plus granulocyte\u2010colony\u2010stimulating factor for the mobilization of hematopoietic stem cells in Chinese patients with non\u2212Hodgkin's lymphoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY DESIGN AND METHODS<\/jats:title>\n                    <jats:p>\n                      Adults (ages 18\u201075 years) with non\u2212Hodgkin's lymphoma in first or second complete or partial remission, without previous hematopoietic stem cell mobilization or autologous transplant, were included. Patients received granulocyte\u2010colony\u2010stimulating factor 10 \u00b5g\/kg\/day from Days 1 through 4 before they were randomized (1:1) to receive either plerixafor 0.24 mg\/kg\/day or placebo subcutaneously on Days 4 through 7 plus continued granulocyte\u2010colony\u2010stimulating factor on Days 5 through 8. Apheresis began on Day 5 and continued for no more than 4 days. The primary endpoint was collection of 5 \u00d7 10\n                      <jats:sup>6<\/jats:sup>\n                      CD34+ cells\/kg or greater over no more than 4 days of apheresis. Other endpoints included the collection of 2 \u00d7 10\n                      <jats:sup>6<\/jats:sup>\n                      CD34+ cells\/kg or greater and safety.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Overall, 101 patients were enrolled, and 50 were randomized to each group. More patients in the plerixafor group achieved 5 \u00d7 10\n                      <jats:sup>6<\/jats:sup>\n                      CD34+ cells\/kg or greater (62 vs. 20%; p\u2009&lt;\u20090.0001) or 2 \u00d7 10\n                      <jats:sup>6<\/jats:sup>\n                      CD34+ cells\/kg or greater (88 vs. 66%) and underwent transplantation (88 vs. 68%) compared with those in the placebo group. The most common plerixafor\u2010related adverse events were nausea (7.8%) and diarrhea (3.9%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Plerixafor plus granulocyte\u2010colony\u2010stimulating factor is superior to placebo plus granulocyte\u2010colony\u2010stimulating factor for the mobilization of CD34+ cells for autologous transplantation and is generally well tolerated in Chinese patients with non\u2212Hodgkin's lymphoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.14426","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T23:11:16Z","timestamp":1513206676000},"page":"81-87","source":"Crossref","is-referenced-by-count":23,"title":["Plerixafor and granulocyte\u2010colony\u2010stimulating factor for mobilization of hematopoietic stem cells for autologous transplantation in Chinese patients with non\u2212Hodgkin's lymphoma: a randomized Phase 3 study"],"prefix":"10.1111","volume":"58","author":[{"given":"Jun","family":"Zhu","sequence":"first","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Lymphoma Unit, Peking University Cancer Hospital and Institute Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sun Yat\u2010sen University Cancer Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University People's Hospital, Peking University Institute of Hematology Beijing 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