{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:40:21Z","timestamp":1789609221916,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T00:00:00Z","timestamp":1512950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Chronic myeloid leukemia (CML) is a common hematologic malignancy; however, its occurrence during pregnancy is unusual due to its low prevalence in females of childbearing age. There are conflicting reports of how to best manage CML in pregnancy, particularly in the setting of leukocytosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hemapheresis<\/jats:title><jats:p>A 30\u2010year\u2010old female was diagnosed with CML at 18 weeks' estimated gestational age. On initial presentation she reported fatigue, night sweats, and early satiety, and was found to have a white blood cell (WBC) count of 69.3 \u00d7 10<jats:sup>9<\/jats:sup>\/L and platelet count of 366 \u00d7 10<jats:sup>9<\/jats:sup>\/L. Her disease was managed during pregnancy using interferon\u2010\u03b1 alone despite persistent leukocytosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>CML may be effectively managed during pregnancy, even in the setting of leukocytosis, without the application of leukocytapheresis. Management relies not only upon the coordination of drug therapy and fetal monitoring, but requires close communication between multiple medical disciplines. Leukocytapheresis has been safely performed during pregnancy and may be a suitable adjunct management strategy in pregnant patients diagnosed with CML with specific clinical presentations, such as hyperleukocytosis (WBC count\u2009&gt;\u2009150 \u00d7 10<jats:sup>9<\/jats:sup>\/L) and\/or symptomatic leukostasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14448","type":"journal-article","created":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T04:16:38Z","timestamp":1513052198000},"page":"456-460","source":"Crossref","is-referenced-by-count":17,"title":["Management of chronic myeloid leukemia in the setting of pregnancy: when is leukocytapheresis appropriate? A case report and review of the literature"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9567-4013","authenticated-orcid":false,"given":"Elizabeth M.","family":"Staley","sequence":"first","affiliation":[{"name":"Division of Laboratory Medicine, Department of Pathology The University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sierra C.","family":"Simmons","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine, Department of Pathology The University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander Z.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine, Department of Pathology The University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin G.","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine, Department of Pathology The University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa B.","family":"Marques","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine, Department of Pathology The University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Lance A.","family":"Williams","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine, Department of Pathology The University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. Long","family":"Zheng","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine, Department of Pathology The University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huy P.","family":"Pham","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine, Department of Pathology The University of Alabama at Birmingham Birmingham Alabama"},{"name":"Department of Pathology Keck School of Medicine of the University of Southern California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2317-z"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2000.047"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000057634"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyh038"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830380316"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1978.tb04606.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089168407000412"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1978.18178118555.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830220213"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.1993.tb00123.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21410"},{"key":"e_1_2_6_13_1","first-page":"147","article-title":"Successful management of chronic myeloid leukaemia with leucapheresis during a twin pregnancy","volume":"65","author":"Klaasen R","year":"2007","journal-title":"Neth J Med"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2015.01.002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1101(1999)14:1<42::AID-JCA8>3.0.CO;2-2"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2015.05.009"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21276"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13210"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2014.028"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0b013e328352a8fe"},{"key":"e_1_2_6_21_1","first-page":"997","article-title":"[Guidelines for the management of nilotinib (Tasigna)\u2010induced side effects in chronic myelogenous leukemia: recommendations of French Intergroup of CML (Fi\u2010LMC group)]","volume":"97","author":"Etienne G","year":"2010","journal-title":"Bull Cancer"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-114900"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1992.tb08202.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-08-283580"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001972"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20476"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200101000-00017"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2016.1205479"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.14448","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.14448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:54:53Z","timestamp":1695495293000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.14448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,11]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/trf.14448"],"URL":"https:\/\/doi.org\/10.1111\/trf.14448","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,11]]}}}