{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:06:53Z","timestamp":1789625213973,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Platelets (PLTs) stored in PLT additive solution (PAS) are associated with fewer allergic reactions than plasma\u2010stored PLTs. However, earlier studies could not provide conclusive evidence on febrile reactions and did not analyze other transfusion reactions separately due to limited sample size. We therefore compared incidences of all transfusion reactions of PAS\u2010B\u2010PLTs, PAS\u2010C\u2010PLTs, and plasma\u2010PLTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>In this observational study, all transfusion reactions reported to the national hemovigilance office of the Netherlands from 2006 to 2015 were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>During the study period, a total of 2407 transfusion reactions after PLT transfusions were reported. In that period 553,267 pooled buffy coat\u2013derived PLT units were issued, of which 83,884 were stored in PAS\u2010B, 45,728 in PAS\u2010C, and 423,655 in plasma. Regarding transfusion\u2010related circulatory overload, transfusion\u2010related acute lung injury, and \u201cother reactions\u201d no significant differences were observed between the PLT products. When PAS\u2010B\u2010PLT transfusions were compared to plasma\u2010PLT transfusions, the overall relative risk (RR; 95% confidence interval [CI]) of transfusion reactions was 0.99 (0.88\u20101.11); for allergic and febrile nonhemolytic transfusion reactions (FNHTRs) it was 0.66 (0.55\u20100.80) and 1.54 (1.27\u20101.86), respectively. When PAS\u2010C\u2010PLTs were compared to plasma\u2010PLTs, the RR (95% CI) was 0.56 (0.46\u20100.68) for all transfusion reactions, 0.38 (0.28\u20100.52) for allergic reactions, and 0.82 (0.59\u20101.13) for FNHTRs. When PAS\u2010C\u2010PLTs were compared to PAS\u2010B\u2010PLTs, for all reactions the RR (95% CI) was 0.56 (0.45\u20100.70) for allergic reactions 0.58 (0.40\u20100.82), and for FNHTRs 0.53 (0.37\u20100.75).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>PAS\u2010C\u2010PLTs are associated with fewer transfusion reactions compared to plasma\u2010PLTs and compared to PAS\u2010B\u2010PLTs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14509","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T06:03:22Z","timestamp":1517897002000},"page":"1021-1027","source":"Crossref","is-referenced-by-count":26,"title":["Transfusion reactions after transfusion of platelets stored in PAS\u2010B, PAS\u2010C, or plasma: a nationwide comparison"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3027-6406","authenticated-orcid":false,"given":"Fabienne M.A.","family":"van Hout","sequence":"first","affiliation":[{"name":"Center for Clinical Transfusion Research, Sanquin Research Leiden the Netherlands"},{"name":"Department of Clinical Epidemiology Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2093-3604","authenticated-orcid":false,"given":"Pieter F.","family":"van der Meer","sequence":"additional","affiliation":[{"name":"Center for Clinical Transfusion Research, Sanquin Research Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna C.","family":"Wiersum\u2010Osselton","sequence":"additional","affiliation":[{"name":"Transfusion and Transplantation Reactions in Patients Dutch National Hemovigilance and Biovigilance Office Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6545-7277","authenticated-orcid":false,"given":"Rutger A.","family":"Middelburg","sequence":"additional","affiliation":[{"name":"Center for Clinical Transfusion Research, Sanquin Research Leiden the Netherlands"},{"name":"Department of Clinical Epidemiology Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin R.","family":"Schipperus","sequence":"additional","affiliation":[{"name":"Transfusion and Transplantation Reactions in Patients Dutch National Hemovigilance and Biovigilance Office Leiden the Netherlands"},{"name":"Department of Hematology Haga Teaching Hospital The Hague the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna G.","family":"van der Bom","sequence":"additional","affiliation":[{"name":"Center for Clinical Transfusion Research, Sanquin Research Leiden the Netherlands"},{"name":"Department of Clinical Epidemiology Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Louis","family":"Kerkhoffs","sequence":"additional","affiliation":[{"name":"Center for Clinical Transfusion Research, Sanquin Research Leiden the Netherlands"},{"name":"Department of Hematology Haga Teaching Hospital The Hague the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12155"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12494"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1993.tb02124.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409083311001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.03008.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03476.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03364.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01918.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12025"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12597"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12498"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-020131"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2000.40040398.x"},{"key":"e_1_2_8_15_1","unstructured":"Blood Transfusion Guideline[Internet].Amsterdam:Sanquin; 2011 [cited2017Mar 20]. 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