{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:49:00Z","timestamp":1762145340092},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Acute splenic sequestration crisis is a complication of sickle cell disease (SCD) occurring when intrasplenic red blood cell (RBC) sickling prevents blood from leaving the spleen, causing acute splenic enlargement. Although typically seen in young children, it has been reported in older children with hemoglobin (Hb)SC disease, eventually resulting in functional asplenia. Ceftriaxone is a frequently used antibiotic of choice for children with SCD, because of its efficacy against invasive pneumococcal disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>CASE REPORT<\/jats:title><jats:p>We report a case of a 9\u2010year\u2010old female with HbSC disease, who had a fatal reaction after receiving a dose of ceftriaxone in the outpatient clinic for fever. Her Hb level decreased abruptly from 9.3 to 2.3 mg\/dL. RBC clumps with no visible hemolysis were observed in the postreaction sample. Autopsy examination revealed marked splenomegaly with acute congestion and sickled cells in the spleen and liver. Serologic testing revealed a positive direct antiglobulin test with polyspecific antibody, anti\u2010C3, and anti\u2010C3d, but negative with anti\u2010immunoglobulin G. Ceftriaxone\u2010dependent RBC antibodies were detected in her serum and RBC eluate when tested in the presence of the drug.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>We report a new presentation of ceftriaxone\u2010induced drug reaction in a patient with SCD mimicking an acute splenic sequestration crisis. Review of the literature for cases of ceftriaxone\u2010induced drug reactions in pediatric patients revealed nine previously reported cases of ceftriaxone\u2010induced immune hemolytic anemia in children with SCD since 1995, but none with an initial presentation suggestive of acute splenic sequestration crisis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14536","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T06:26:24Z","timestamp":1519367184000},"page":"879-883","source":"Crossref","is-referenced-by-count":6,"title":["Ceftriaxone\u2010induced drug reaction mimicking acute splenic sequestration crisis in a child with hemoglobin SC disease"],"prefix":"10.1111","volume":"58","author":[{"given":"Nancy L.","family":"Van Buren","sequence":"first","affiliation":[{"name":"Transfusion Services"},{"name":"Innovative Blood Resources, St Paul  Minnesota."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jed B.","family":"Gorlin","sequence":"additional","affiliation":[{"name":"Transfusion Services"},{"name":"Innovative Blood Resources, St Paul  Minnesota."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn C.","family":"Reed","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome L.","family":"Gottschall","sequence":"additional","affiliation":[{"name":"BloodCenter of Wisconsin Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen C.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Cancer and Blood Disorders Children's Hospitals and Clinics of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/516781"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182a11808"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70417-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200001000-00019"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5858\/2004-128-905-ACOAHA"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pec.0000159053.64930.2d"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000161285.12396.FF"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181b7eda2"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e3182131fa8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028014548310"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000181"},{"key":"e_1_2_8_13_1","first-page":"316","article-title":"Incidence and predictors of bacterial infection and febrile children with sickle cell disease","volume":"39","author":"Morrissey BJ","year":"2015","journal-title":"Hemoglobin"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.11.025"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26713"},{"key":"e_1_2_8_16_1","volume-title":"Immune hemolytic anemias","author":"Petz LD","year":"2004"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.21307\/immunohematology-2019-440","article-title":"Review: drug\u2010induced immune hemolytic anemia\u2014the last decade","volume":"20","author":"Garratty G.","year":"2004","journal-title":"Immunohematology"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.14536","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.14536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:38:28Z","timestamp":1695537508000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.14536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,22]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/trf.14536"],"URL":"https:\/\/doi.org\/10.1111\/trf.14536","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,22]]}}}