{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:49:13Z","timestamp":1789008553837,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:00:00Z","timestamp":1520985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research and Transfusion Association of the French Blood Service"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>A better knowledge of the connections between platelet concentrate (PC) characteristics and transfusion outcomes in day\u2010to\u2010day practice would help improve the selection process of the most appropriate PC.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>In this study of prophylactic platelet transfusions in patients with hematologic malignancies between 2002 and 2012, outcome criteria were corrected count increments (CCIs) and platelet transfusion intervals (TIs, in days). Studied characteristics were ABO matching status, platelet source, dose, storage duration, irradiation, washing, and transfusion sequence number (TSN). The analysis consisted of multivariable linear mixed\u2010effects models with adjustments for patient diagnosis, sex, and type of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Overall, 869 patients and 6662 platelet transfusions were analyzed. For each day after the second day of storage, the CCI and TI decreased by 0.88 and 0.06 day, respectively. Compared to ABO\u2010identical, transfusion with major ABO\u2010incompatible PCs decreased the CCI and TI by 0.79 and 0.21 day, respectively. Platelet washing reduced the CCI and TI by 2.28 and 0.24 day, respectively. There was no significant association between platelet source or irradiation and CCI or TI. TI increased as the platelet dose per kg increased. Both CCI and TI decreased as the TSN increased.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Transfusion outcomes were significantly related to several PC\u2010related factors. Associations for ABO matching status and storage duration were stronger than previously reported. Taking into account such factors when selecting a PC for transfusion could be beneficial to the recipient.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14592","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T12:30:39Z","timestamp":1521117039000},"page":"1377-1387","source":"Crossref","is-referenced-by-count":10,"title":["Factors related to the outcome of prophylactic platelet transfusions in patients with hematologic malignancies: an observational study"],"prefix":"10.1111","volume":"58","author":[{"given":"Audrey","family":"Seigeot","sequence":"first","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang Bourgogne\u2010Franche\u2010Comt\u00e9 Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Desmarets","sequence":"additional","affiliation":[{"name":"CHRU Besan\u00e7on, Centre d'Investigation Clinique Inserm 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