{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:00:59Z","timestamp":1788786059489,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:00:00Z","timestamp":1520985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Oral chronic graft\u2010versus\u2010host disease (cGvHD) impairs oral function and patients' quality of life. Some lesions are refractory to local and systemic immunosuppressive therapy, and new therapeutic modalities are required. The aim of the study was to assess the efficacy and safety of topical application of autologous platelet gel (PG) in patients with oral cGvHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>PG was prepared from autologous blood and applied on ulcerous lesions using an automated system. The oral cGvHD was assessed using the 273\u2010point Oral Mucositis Rating Scale (OMRS) prior and after completion of the PG treatment. The overall response to treatment of particular topography expressed as the total score on OMRS was compared to total score on National Institutes of Health cGvHD Oral Mucosal Score (NIH OMS). The pain intensity was measured by the Numeric Pain Rating Scale (NRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In five patients, 12 autologous blood collections were performed; median 3 (range 1\u20103) per patient, and 26 PG applications were performed; median 6 (range 2\u20108) per patient. PG applications reduced lesions in oral cGvHD: median OMRS total score was reduced for 43.2% (range 9.6%\u201047.3%), and median NIH OMS total score for 27.3% (range 20.0%\u201050.0%) from baseline values. Median of pain intensity reduction on NRS scale was 57.1% (range 50%\u2010100%). No side effects were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Application of autologous PG in oral cGvHD showed as an efficient and safe treatment option for patients who do not respond to standard local treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14594","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T12:29:50Z","timestamp":1521116990000},"page":"1494-1499","source":"Crossref","is-referenced-by-count":12,"title":["Autologous blood as a source of platelet gel for the effective and safe treatment of oral chronic graft\u2010versus\u2010host disease"],"prefix":"10.1111","volume":"58","author":[{"given":"Ines","family":"Bojanic","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine and Transplantation Biology University Hospital Center Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinka","family":"Mravak Stipetic","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine University Hospital Center Zagreb Zagreb Croatia"},{"name":"University of Zagreb, School of Dental Medicine Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drazen","family":"Pulanic","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine University Hospital Center Zagreb Zagreb Croatia"},{"name":"University of Zagreb, School of Medicine Zagreb Croatia"},{"name":"J. 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Strossmayer University of Osijek, Faculty of Medicine Osijek Osijek Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lana","family":"Desnica","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine University Hospital Center Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Mazic","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Transplantation Biology University Hospital Center Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branka","family":"Golubic Cepulic","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Transplantation Biology University Hospital Center Zagreb Zagreb Croatia"},{"name":"University of Zagreb, School of Medicine Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranka","family":"Serventi Seiwerth","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine University Hospital Center Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radovan","family":"Vrhovac","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine University Hospital Center Zagreb Zagreb Croatia"},{"name":"University of Zagreb, School of Medicine Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damir","family":"Nemet","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine University Hospital Center Zagreb Zagreb Croatia"},{"name":"University of Zagreb, School of Medicine Zagreb Croatia"},{"name":"J. 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Strossmayer University of Osijek, Faculty of Medicine Osijek Osijek Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven Z.","family":"Pavletic","sequence":"additional","affiliation":[{"name":"National Cancer Institute, Center for Cancer Research, NIH Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2013.137"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.09.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.12.001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12028"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920515)69:10<2469::AID-CNCR2820691015>3.0.CO;2-W"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2006.01.008"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.02.025"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2014.11.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000183"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02439.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3325\/cmj.2016.57.1"},{"key":"e_1_2_8_13_1","first-page":"193","volume-title":"Guide to the preparation, use and quality assurance of blood components. 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