{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:50:36Z","timestamp":1775065836849,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,29]],"date-time":"2018-04-29T00:00:00Z","timestamp":1524960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201011\u2010B5V1\u20100024"],"award-info":[{"award-number":["ANR\u201011\u2010B5V1\u20100024"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Sickle cell disease (SCD) patients undergo multiple red blood cell (RBC) transfusions and are regularly exposed to low\u2010prevalence (LP) antigens specific to individuals of African descent. This study evaluated the prevalence of antibodies against LP antigens in SCD patients and the need to identify these antibodies in everyday practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>Plasma from 211 SCD patients was tested with RBCs expressing the following LP antigens: RH10 (V), RH20 (VS), RH23 (D<jats:sup>W<\/jats:sup>), RH30 (Go<jats:sup>a<\/jats:sup>), KEL6 (Js<jats:sup>a<\/jats:sup>), and MNS6 (He).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Nine LP antibodies were found in eight patients (3.8%): five anti\u2010RH23, two anti\u2010RH30, and two anti\u2010MNS6. The exposure risk, calculated for each LP antigen, was below 3% per RBC unit, for all antigens tested. Thus, in this cohort of transfused SCD patients, the prevalence of LP antibodies was similar to that of antibodies against antigens of the FY, JK, and MNS blood group systems. These findings also reveal the occurrence of anti\u2010RH23 in SCD patients. No anti\u2010RH20 or anti\u2010KEL6 were found, despite the high frequency of mismatch situations.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>These results highlight the immunogenicity of these LP antigens, and the evanescence of antibodies against LP antigens. They also highlight the importance of appropriate pretransfusion testing for patients frequently transfused, who are likely to be exposed to multiple types of blood group antigens.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14633","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T05:00:52Z","timestamp":1525064452000},"page":"1527-1535","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["High immunogenicity of red blood cell antigens restricted to the population of African descent in a cohort of sickle cell disease patients"],"prefix":"10.1111","volume":"58","author":[{"given":"Aline","family":"Floch","sequence":"first","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang (EFS)\u2013Ile de France Cr\u00e9teil"},{"name":"INSERM U955, Equipe 2 \u201cTransfusion et maladies du globule rouge\u201d Cr\u00e9teil"},{"name":"Laboratory of Excellence GR\u2010Ex Cr\u00e9teil 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