{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T04:44:24Z","timestamp":1782362664493,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T00:00:00Z","timestamp":1535587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Gamma irradiation of red blood cells (RBCs) is well recognized to exacerbate storage lesion formation, but the effect of storage after irradiation on in vivo oxygen delivery capacity of transfused RBCs is currently not known.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>In 24 preterm infants with anemia receiving nonurgent transfusion of irradiated RBCs, we examined cerebral regional tissue oxygenation (crSO<jats:sub>2<\/jats:sub>) and time spent with peripheral arterial saturation (SpO<jats:sub>2<\/jats:sub>) less than 88%. Physiologic data were obtained immediately before, immediately after, and 5 days after transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>We observed linear negative moderate correlations between time since irradiation and the magnitude of change in crSO<jats:sub>2<\/jats:sub> (r\u2009=\u2009\u20130.60; 95% CI, \u20130.81 to \u20130.27; p\u2009=\u20090.0018) and time spent with SpO<jats:sub>2<\/jats:sub> of less than 88% (r\u2009=\u2009\u20130.42; 95% CI, \u20130.71 to 0.003; p\u2009=\u20090.04) immediately after transfusion. In infants (n\u2009=\u20099) who received fresher RBCs (irradiated\u2009&lt;10 days before transfusion), there was a sustained increase in mean crSO<jats:sub>2<\/jats:sub> up to 5 days after transfusion (3.0%; 95% CI, 0.3% to 5.7%; p\u2009=\u20090.04). Conversely, in infants (n\u2009=\u200915) who received older RBCs (irradiated\u2009\u226510 days before transfusion), there were negligible changes in crSO<jats:sub>2<\/jats:sub> after transfusion at any time point.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Our findings indicate that storage after gamma irradiation may have a detrimental effect on the oxygen delivery capacity of RBCs given to anemic preterm infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14764","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T18:23:42Z","timestamp":1535653422000},"page":"2108-2112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Storage after gamma irradiation affects in vivo oxygen delivery capacity of transfused red blood cells in preterm infants"],"prefix":"10.1111","volume":"58","author":[{"given":"Maria","family":"Saito\u2010Benz","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Child Health"},{"name":"Centre for Translational Physiology University of Otago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Murphy","sequence":"additional","affiliation":[{"name":"NZ Blood Service, Wellington Regional Hospital Wellington New Zealand"},{"name":"School of Medicine and Medical Science University College Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Chieh","family":"Tzeng","sequence":"additional","affiliation":[{"name":"Centre for Translational Physiology University of Otago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Atkinson","sequence":"additional","affiliation":[{"name":"School of Health and Social Care Teesside University Middlesbrough North Yorkshire United 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