{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T18:23:22Z","timestamp":1789323802146,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T00:00:00Z","timestamp":1536624000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The short dating period of room temperature\u2013stored platelets (PLTs; 5\u20107 days) limits their availability at far\u2010forward combat facilities and at remote civilian sites in the United States. PLT cryopreservation in 6% DMSO and storage for up to 2 years may improve timely availability for bleeding patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>A dose escalation trial of DMSO\u2010cryopreserved PLTs (CPPs) compared to standard liquid\u2010stored PLTs (LSPs) was performed in bleeding patients with thrombocytopenia. Within each of four cohorts, six patients received escalating doses of CPP (0.5 unit, 1 unit, and sequential transfusions of 2 and 3 units) and one received a LSP transfusion. Patients were monitored for adverse events (AEs), coagulation markers, PLT responses, and hemostatic efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Patients with a World Health Organization bleeding score of 2 or more received from 0.5 to 3 units of CPP (n\u2009=\u200924) or 1 unit of LSP (n\u2009=\u20094). There were no related thrombotic or other serious AEs experienced. Mild transfusion\u2010related AEs of chills and fever (n\u2009=\u20091), transient increased respiratory rate (n\u2009=\u20091), DMSO\u2010related skin odor (n\u2009=\u20092), and headache (n\u2009=\u20091) were observed after CPP transfusion. Among CPP recipients 14 of 24 (58%) had improved bleeding scores, including three of seven (43%) patients who had intracerebral bleeding. CPP posttransfusion PLT increments were significantly less than those of LSPs; however, days to next transfusion were the same. After transfusion, the CPP recipients had improvements in some variables of thrombin generation tests and thromboelastography.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Cryopreserved PLT transfusions appear to be safe and effective when given to bleeding patients with thrombocytopenia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14780","type":"journal-article","created":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T21:29:19Z","timestamp":1536701359000},"page":"2129-2138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Safety and efficacy of cryopreserved platelets in bleeding patients with thrombocytopenia"],"prefix":"10.1111","volume":"58","author":[{"given":"Sherrill J.","family":"Slichter","sequence":"first","affiliation":[{"name":"Research Institute, Bloodworks Northwest Seattle Washington"},{"name":"University of Washington School of Medicine Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry J.","family":"Dumont","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth and Dartmouth\u2010Hitchcock Medical Center Lebanon New Hampshire"},{"name":"Blood Systems Research Institute Denver Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Cancelas","sequence":"additional","affiliation":[{"name":"Hoxworth Blood Center University of Cincinnati Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MeLinh","family":"Jones","sequence":"additional","affiliation":[{"name":"Research Institute, Bloodworks Northwest Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry B.","family":"Gernsheimer","sequence":"additional","affiliation":[{"name":"University of Washington School of Medicine Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbigniew M.","family":"Szczepiorkowski","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth and Dartmouth\u2010Hitchcock Medical Center Lebanon New Hampshire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy M.","family":"Dunbar","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth and Dartmouth\u2010Hitchcock Medical Center Lebanon New Hampshire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautham","family":"Prakash","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth and Dartmouth\u2010Hitchcock Medical Center Lebanon New Hampshire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Medlin","sequence":"additional","affiliation":[{"name":"University of Cincinnati Health Hospital Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeta","family":"Rugg","sequence":"additional","affiliation":[{"name":"Hoxworth Blood Center University of Cincinnati Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget","family":"Kinne","sequence":"additional","affiliation":[{"name":"University of Cincinnati Health Hospital Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor W.","family":"Macdonald","sequence":"additional","affiliation":[{"name":"U.S. Army Medical Research and Materiel Command Fort Detrick Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greggory","family":"Housler","sequence":"additional","affiliation":[{"name":"U.S. Army Medical Research and Materiel Command Fort Detrick Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Valiyaveettil","sequence":"additional","affiliation":[{"name":"U.S. Army Medical Research and Materiel Command Fort Detrick Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hmel","sequence":"additional","affiliation":[{"name":"Fast\u2010Track Drugs &amp; 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