{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:44:55Z","timestamp":1788367495904,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T00:00:00Z","timestamp":1537142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The Gram\u2010negative bacillus <jats:italic>Capnocytophaga canimorsus<\/jats:italic> may cause a severe illness resembling thrombotic thrombocytopenic purpura (TTP). The pathogenesis and optimal therapy of this secondary thrombotic microangiopathy (TMA) remain uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>CASE REPORT<\/jats:title><jats:p>A 63\u2010year\u2010old Caucasian man was admitted with suspicion for TTP, but blood cultures grew <jats:italic>C. canimorsus<\/jats:italic>. Initial investigations revealed severe thrombocytopenia, a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) activity level of less than 1%, and strongly elevated D\u2010dimer and lactate dehydrogenase levels. He made a full recovery with antibiotics and plasma infusion for 3 days. Plasmapheresis was not performed. Retrospective determination of serial ADAMTS13 activity levels revealed that ADAMTS13 activity had already increased to 25% at the start of plasma infusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>This case highlights that a <jats:italic>C. canimorsus<\/jats:italic> sepsis may cause a secondary TMA with a severe ADAMTS13 deficiency. It also illustrates that the adjunctive role of plasma exchange or plasma infusion is doubtful as ADAMTS13 activity levels increased with antibiotics alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14829","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T18:02:13Z","timestamp":1537207333000},"page":"2426-2429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Secondary thrombotic microangiopathy with severely reduced ADAMTS13 activity in a patient with <i>Capnocytophaga canimorsus<\/i> sepsis: a case report"],"prefix":"10.1111","volume":"58","author":[{"given":"Nori J.L.","family":"Smeets","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Fijnheer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Meander Medical Center  Amersfoort the Netherlands"},{"name":"Department of Clinical Chemistry and Haematology University Medical Center  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvie","family":"Sebastian","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Haematology University Medical Center  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quirijn","family":"De Mast","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-015-2360-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-5-695"},{"key":"e_1_2_6_4_1","first-page":"167","article-title":"Hemolytic uremic syndrome after Capnocytophaga canimorsus (DF\u20102) septicemia","volume":"55","author":"Mulder AH","year":"2001","journal-title":"Clin Nephrol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.ndt.a027679"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90517-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-09-0731"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-08-508093"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.1999.tb00147.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e318262db1a"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc5064"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811263392202"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4161\/org.7.1.14027"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-788026"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080130"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1505533"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.14829","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.14829","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T11:47:07Z","timestamp":1694864827000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.14829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,17]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/trf.14829"],"URL":"https:\/\/doi.org\/10.1111\/trf.14829","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,17]]},"assertion":[{"value":"2017-10-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}