{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:32:41Z","timestamp":1772987561837,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T00:00:00Z","timestamp":1538784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T00:00:00Z","timestamp":1538784000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Extracorporeal photopheresis (ECP) has been established to treat graft\u2010versus\u2010host disease. Our mini ECP technique (mini\u2010ECP) allows for treatment of patients with GVHD and contraindications for classical ECP or low body weight. The safety and efficacy of applying ECP for the long\u2010term treatment of chronic GVHD (cGVHD) have not been described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY DESIGN AND METHODS<\/jats:title>\n                    <jats:p>A retrospective analysis of mini\u2010ECP treatments for children and adolescents with cGVHD was performed. Mini\u2010ECP with 100 to 200 mL of whole blood was used to treat 14 patients. The median age at the start of treatment was 7 years (range, 1\u201017 years), and median body weight was 20 kg (range, 8\u201053 kg). A total of 703 mini\u2010ECP treatments was performed. The median number of treatments per patient was 35 (range, 8\u2010129), and median treatment duration was 11 months (range, 1.4\u201028.5 months).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Mini\u2010ECP was well tolerated. Four adverse events occurred in three patients, and two of them were related to the ECP procedure. Complete or partial responses were observed in 10 patients. Steroids were discontinued in seven patients and tapered in three others. Responses were seen in the skin, mouth, gastrointestinal tract, and eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Mini\u2010ECP represents a less invasive ECP alternative for low\u2010body\u2010weight patients with cGVHD and contraindications for apheresis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.14880","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T10:55:35Z","timestamp":1538823335000},"page":"2495-2500","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Mini photopheresis for refractory chronic graft\u2010versus\u2010host disease in children and adolescents"],"prefix":"10.1111","volume":"58","author":[{"given":"Jaime","family":"Verd\u00fa\u2010Amor\u00f3s","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Justus\u2010Liebig\u2010University  Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilhelm","family":"Woessmann","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Justus\u2010Liebig\u2010University  Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britta","family":"Maecker\u2010Kolhoff","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Hannover Medical School  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ansgar","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Medical Center Ulm  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Strauss","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Helios Klinikum Berlin\u2010Buch  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Bein","sequence":"additional","affiliation":[{"name":"Institute for Clinical Immunology and Transfusion Medicine Justus\u2010Liebig\u2010University  Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Hackstein","sequence":"additional","affiliation":[{"name":"Institute for Clinical Immunology and Transfusion Medicine Justus\u2010Liebig\u2010University  Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation.V2012.1.251.3798879"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/bbmt.2003.50003"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60237-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.05.004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.108217"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-3907"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-141481"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20231"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12596"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02289.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-0502(02)00101-5"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.12.001"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.02.025"},{"key":"e_1_2_8_15_1","unstructured":"National Cancer Institute.Common terminology criteria for adverse events v4.0 NCI NIH DHHS [2009 May 29] NIH publication # 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