{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:38:17Z","timestamp":1791545897571,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Intravenous immunoglobulin (IVIG) contains immunoglobulin G against various viruses, except those that have been screened, such as human immunodeficiency and hepatitis C viruses. Antivirus titers reflect the serostatus of the blood donor population in the collection region and are of clinical interest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY DESIGN AND METHODS<\/jats:title>\n                    <jats:p>During the past 10 years, measles, mumps, rubella, varicella\u2010zoster, hepatitis A and B, Epstein\u2010Barr, and human respiratory syncytial viruses; human parainfluenza viruses 1, 2, and 3; human herpes simplex viruses 1 and 2; human herpesvirus 6; cytomegalovirus (CMV); human adenoviruses (HAdVs) 1, 2, 3, 7, and 11; human parvovirus B19; and human echovirus 9 and 11 titers in IVIG lots have been measured by a commercial testing facility. A viral neutralizing assay for CMV has been used at our facility. Herein, we summarize the measurements and results of a regression analysis of the trends in virus antibody titers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>IVIG lots contained significant titers against all of the above viruses, except for HAdV 7. Three patterns\u2014stable, increasing, and decreasing\u2014were observed, without any drastic changes. Although these trends reflect the seroprevalence in Japan, the titers were not obviously affected by the cycle of epidemics. On the other hand, the prevalence data suggest that titers against hepatitis A virus and other viruses will decrease in the near future, although they are currently stable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Monitoring the titer of IVIG lots and seroprevalence of donor populations is important for anticipating future changes in virus antibody titers of IVIG lots and can provide useful information of clinical interest.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.14908","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T16:09:00Z","timestamp":1538755740000},"page":"2617-2626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Long\u2010term monitoring of virus antibody titers in human intravenous immunoglobulin lots derived from donors in Japan"],"prefix":"10.1111","volume":"58","author":[{"given":"Hiroyuki","family":"Onodera","sequence":"first","affiliation":[{"name":"Medical Information Department Japan Blood Products Organization  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risa","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Medical Information Department Japan Blood Products Organization  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Research and Development Division Japan Blood Products Organization  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeru","family":"Urayama","sequence":"additional","affiliation":[{"name":"Research and Development Division Japan Blood Products Organization  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyuki","family":"Haino","sequence":"additional","affiliation":[{"name":"Biomet K.K.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1548-5894","authenticated-orcid":false,"given":"Mikihiro","family":"Yunoki","sequence":"additional","affiliation":[{"name":"Research and Development Division Japan Blood Products Organization  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,4]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Japan Blood Products Association.Indication of immunoglobulin preparations. Available at:http:\/\/www.ketsukyo.or.jp\/plasma\/globulin\/glo_07_01.html[in Japanese]. Accessed August 3 2017."},{"key":"e_1_2_10_3_1","first-page":"23","article-title":"Neutralizing activities against seasonal influenza viruses in human intravenous immunoglobulin","volume":"11","author":"Onodera H","year":"2017","journal-title":"Biologics"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.08016.x"},{"key":"e_1_2_10_5_1","first-page":"245","article-title":"Significant neutralizing activities against H2N2 influenza A viruses in human intravenous immunoglobulin lots manufactured from 1993 to 2010","volume":"6","author":"Kubota\u2010Koketsu R","year":"2012","journal-title":"Biologics"},{"key":"e_1_2_10_6_1","first-page":"99","article-title":"Neutralizing activities of human immunoglobulin derived from donors in Japan against mosquito\u2010borne flaviviruses, Japanese encephalitis virus, West Nile virus, and dengue virus","volume":"10","author":"Yunoki M","year":"2016","journal-title":"Biologics"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1510.081668"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2807\/ese.16.10.19812-en"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12294"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/hyb.1992.11.569"},{"key":"e_1_2_10_11_1","unstructured":"Ministry of Health Labor and Welfare Japan.Human Blood Management in Japan.2017. Available at:http:\/\/www.mhlw.go.jp\/stf\/seisakunitsuite\/bunya\/0000197659.html[in Japanese]. Accessed April 16 2018."},{"key":"e_1_2_10_12_1","first-page":"147","article-title":"Idiopathic rash\u2010current status of antibody testing [in Japanese]","volume":"16","author":"Asano Y","year":"1989","journal-title":"Clin Microbiol"},{"key":"e_1_2_10_13_1","first-page":"89","article-title":"Antibody examination: the purpose, the results, and the next steps","volume":"23","author":"Ihara T","year":"2011","journal-title":"J Pediatr Infect Dis Immunol"},{"key":"e_1_2_10_14_1","unstructured":"Ministry of Health Labor and Welfare.2016. Ketsueki\u2010jigyo houkoku (blood operation report in Japan). Available at:http:\/\/www.mhlw.go.jp\/stf\/seisakunitsuite\/bunya\/0000114506.html[in Japanese]. Accessed September 6 2017."},{"key":"e_1_2_10_15_1","unstructured":"Infectious diseases weekly report comparison graph with the past 10 years (weekly report). Available at:https:\/\/www.niid.go.jp\/niid\/ja\/10\/weeklygraph.html. Accessed December 21 2017."},{"key":"e_1_2_10_16_1","unstructured":"Infectious diseases weekly report comparison graph with the past 10 years (monthly report). Available at:https:\/\/www.niid.go.jp\/niid\/ja\/10\/monthlygraph.html. Accessed December 21 2017."},{"key":"e_1_2_10_17_1","unstructured":"Yearly reports of virus isolation\/detection from human sources 2001\u20132010. Available at:https:\/\/www.niid.go.jp\/niid\/images\/iasr\/table\/virus\/adv01-10.pdf. Accessed April 16 2018."},{"key":"e_1_2_10_18_1","unstructured":"Yearly reports of virus isolation\/detection from human sources 2011\u20132016. Available at:https:\/\/www.niid.go.jp\/niid\/images\/iasr\/archive\/2016\/virus\/adv1116.pdf. Accessed April 16 2018."},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6639a2"},{"key":"e_1_2_10_20_1","unstructured":"Routine\/voluntary immunization schedule in Japan (October 1 2016). Available at:https:\/\/www.niid.go.jp\/niid\/images\/vaccine\/schedule\/2016\/EN20161001.pdf. Accessed April 16 2018."},{"key":"e_1_2_10_21_1","unstructured":"Vaccine schedule from 2012 [in Japanese]. Available at:http:\/\/idsc.nih.go.jp\/vaccine\/dschedule.html. Accessed April 16 2018."},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.09.008"},{"key":"e_1_2_10_23_1","first-page":"593","article-title":"Prevention for hepatitis A [in Japanese]","volume":"73","author":"Kawaguchi T","year":"2015","journal-title":"Nippon Rinsho"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.JJID.2015.366"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.14908","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.14908","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.14908","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.14908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:03:07Z","timestamp":1772967787000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.14908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,4]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/trf.14908"],"URL":"https:\/\/doi.org\/10.1111\/trf.14908","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,4]]},"assertion":[{"value":"2018-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}