{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:06:33Z","timestamp":1781712393737,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T00:00:00Z","timestamp":1542585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Data are limited on the long\u2010acting granulocyte\u2010colony stimulating factors (G\u2010CSFs) pegfilgrastim (PEG) and lipegfilgrastim (LIPEG) compared with filgrastim (FIL) regarding the mobilization efficiency of CD34<jats:sup>+<\/jats:sup> cells, graft cellular composition, and engraftment.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>In this prospective nonrandomized study, 36 patients with non\u2010Hodgkin lymphoma received FIL, 67 received PEG, and 16 patients received LIPEG as a cytokine after chemotherapy. We analyzed the mobilization and collection of CD34<jats:sup>+<\/jats:sup> cells, cellular composition of blood grafts, and hematologic recovery after auto\u2010SCT according to the type of G\u2010CSF used.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Patients in the LIPEG group had fewer apheresis sessions (1 vs. 2, p = 0.021 for FIL and p = 0.111 for PEG) as well as higher median blood CD34<jats:sup>+<\/jats:sup> cell counts at the start of the first apheresis (LIPEG 74 \u00d7 10<jats:sup>6<\/jats:sup>\/L vs. FIL 31 \u00d7 10<jats:sup>6<\/jats:sup>\/L, p = 0.084 or PEG 27 \u00d7 10<jats:sup>6<\/jats:sup>\/L, p = 0.021) and CD34<jats:sup>+<\/jats:sup> yields of the first apheresis (FIL 5.1 \u00d7 10<jats:sup>6<\/jats:sup>\/kg vs. FIL 2.3 \u00d7 10<jats:sup>6<\/jats:sup>\/kg, p = 0.105 or PEG 1.8 \u00d7 10<jats:sup>6<\/jats:sup>\/kg, p = 0.012). Also, the costs associated with G\u2010CSF mobilization and apheresis were lower in the LIPEG group. The graft composition was comparable except for the higher infused CD34<jats:sup>+<\/jats:sup> cell counts in the LIPEG group. The engraftment kinetics were significantly slower in the FIL group.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>LIPEG appears to be more efficient compared with PEG after chemotherapy to mobilize CD34<jats:sup>+<\/jats:sup> cells for auto\u2010SCT demonstrated as fewer sessions of aphereses needed as well as 2.8\u2010fold CD34<jats:sup>+<\/jats:sup> cell yields on the first apheresis day. Early hematologic recovery was more rapid in the LIPEG group. Thus further studies on LIPEG in the mobilization setting are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14993","type":"journal-article","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T10:24:15Z","timestamp":1542623055000},"page":"325-334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of filgrastim, pegfilgrastim, and lipegfilgrastim added to chemotherapy for mobilization of CD34<sup>+<\/sup> cells in non\u2010Hodgkin lymphoma patients"],"prefix":"10.1111","volume":"59","author":[{"given":"A.","family":"Partanen","sequence":"first","affiliation":[{"name":"Department of Medicine Kuopio University Hospital  Kuopio Finland"},{"name":"Department of Clinical Medicine University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Valtola","sequence":"additional","affiliation":[{"name":"Department of Medicine Kuopio 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