{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:40:23Z","timestamp":1789609223930,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Chronic myeloid leukemia (CML) is rarely diagnosed in pregnant women.<\/jats:p><\/jats:sec><jats:sec><jats:title>CASE REPORT<\/jats:title><jats:p>We report a case of a pregnant woman who presented with a leukocyte count of 250 \u00d7 10<jats:sup>9<\/jats:sup> cells\/L at gestational age (GA) 26 weeks and was diagnosed with CML in the chronic phase. Because the patient deliberately opted out of interferon \u03b1 and tyrosine kinase inhibitor treatment, the main goal was to reduce the leukocyte count to postpone delivery beyond the number of weeks considered severely premature and avoid thromboembolic complications while continuously evaluating the clinical safety of the mother and fetus. Hence therapeutic leukapheresis was initiated, and we report the first application of an apheresis approach for this procedure using the Spectra Optia instrument without sedimentation agents. Leukapheresis was conducted 2 to 4 times per week for 9 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>During treatment the leukocyte count decreased remarkably, and the patient developed lymphopenia together with a paradoxical increase in her blood platelet count. Premature labor was induced at GA 35 weeks, and a healthy boy was delivered. Thereafter, the patient initiated imatinib treatment and was in major molecular and complete cytogenetic remission after 1 year. Despite the remarkable reduction of the leukocyte count, we observed a pronounced increase in expression of BCR\u2010ABL1 transcripts, implying the need for close monitoring of patients with CML during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>We report a pregnant woman who was diagnosed with CML and treated solely with apheresis procedures using the Spectra Optia instrument for 9 weeks, ensuring the safe delivery of her child.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15006","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T11:03:02Z","timestamp":1541415782000},"page":"39-45","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Apheresis principles in a patient with chronic myeloid leukemia during pregnancy: challenges in cell separation and assessing transcript levels"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7858-0488","authenticated-orcid":false,"given":"Kit Peiter","family":"Lund","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology Rigshospitalet, University Hospital of Copenhagen  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Torp","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Haematology Rigshospitalet, University hospital of Copenhagen  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Kannik","family":"Haastrup","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Rigshospitalet, University Hospital of Copenhagen  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit Woetman","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Juliane Marie Centre for Children, Women and Reproduction, Rigshospitalet, University hospital of Copenhagen  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa Leth","family":"Maroun","sequence":"additional","affiliation":[{"name":"Department of Pathology Rigshospitalet, University hospital of Copenhagen  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten Tolstrup","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Rigshospitalet, University Hospital Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole Weis","family":"Bjerrum","sequence":"additional","affiliation":[{"name":"Department of Haematology Rigshospitalet, University hospital of Copenhagen  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Fischer\u2010Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Rigshospitalet, University Hospital of 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