{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T20:54:58Z","timestamp":1783803298454,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,10]],"date-time":"2018-11-10T00:00:00Z","timestamp":1541808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000014","name":"Canadian Blood Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000008","name":"Health Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000008","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>There is recent support for long\u2010term adverse effects of donor\u2010recipient sex\u2010mismatched red blood cell (RBC) transfusion, but short\u2010term impact is unknown. A retrospective exploratory analysis was performed using data from a research database.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Adults admitted to hospitals in one Canadian center who received RBCs (2008\u20132014 [3 sites]; 2012\u20132014 [1 site]) were eligible. Patient data were extracted from a research database and donor data from the blood supplier. Cox regression models were used, with control of risk and confounding variables as covariates or using stratification. Exposure was defined by mutually exclusive categories. The outcome was in\u2010hospital mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 25,219 adults received 97,886 RBCs. Diagnoses included cardiovascular (28.8%), neoplastic (15.6%), traumatic (15.4%), or gastrointestinal (10.5%); 56.3% of transfused RBCs were male donors, and median donor age was 45 years (interquartile range, 30\u201354). Female patients exposed to male RBCs experienced a higher risk of in\u2010hospital death (hazard ratio [HR], 1.31; 95% confidence interval [CI], 1.02\u20131.69; p = 0.038) compared to exclusive female RBC exposure. Exposure to RBCs from donors aged 45 years or younger was associated with a higher in\u2010hospital death (HR, 1.21; 95% CI, 1.02\u20131.44; p = 0.026) compared to exclusive RBC exposure to donors older than 45 years. Donor\u2010recipient sex\u2010mismatched RBC exposure (vs. exclusively sex\u2010matched) and RBC exposure from donors aged 45 years or younger (vs. exclusively RBCs from donors &gt;45) were associated with increased mortality: sex\u2010mismatched (HR, 1.23; (95% CI, 1.04\u20131.45; p = 0.017); donors aged 45 years or younger (HR, 1.21; (95% CI, 1.02\u20131.43; p = 0.031).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Donor\u2010recipient sex\u2010matched RBC transfusions and transfusions from older donors may benefit patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15011","type":"journal-article","created":{"date-parts":[[2018,11,10]],"date-time":"2018-11-10T11:44:53Z","timestamp":1541850293000},"page":"482-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["The association between blood donor sex and age and transfusion recipient mortality: an exploratory analysis"],"prefix":"10.1111","volume":"59","author":[{"given":"Nancy M.","family":"Heddle","sequence":"first","affiliation":[{"name":"McMaster Centre for Transfusion Research McMaster University  Hamilton Ontario Canada"},{"name":"Department of Medicine, Faculty of Health Sciences McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Cook","sequence":"additional","affiliation":[{"name":"McMaster Centre for Transfusion Research McMaster University  Hamilton Ontario Canada"},{"name":"Department of Statistics and Actuarial Science University of Waterloo  Waterloo Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"McMaster Centre for Transfusion Research McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Zeller","sequence":"additional","affiliation":[{"name":"McMaster Centre for Transfusion Research McMaster University  Hamilton Ontario Canada"},{"name":"Department of Medicine, Faculty of Health Sciences McMaster University  Hamilton Ontario Canada"},{"name":"Medical Office Canadian Blood Services  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Barty","sequence":"additional","affiliation":[{"name":"McMaster Centre for Transfusion Research McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason P.","family":"Acker","sequence":"additional","affiliation":[{"name":"Centre for Innovation Canadian Blood Services  Edmonton Alberta Canada"},{"name":"Department of Laboratory Medicine and Pathology University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Eikelboom","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Health Sciences McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald M.","family":"Arnold","sequence":"additional","affiliation":[{"name":"McMaster Centre for Transfusion Research McMaster University  Hamilton Ontario Canada"},{"name":"Department of Medicine, Faculty of Health Sciences McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1700464"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2011.03.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2011.01487.x"},{"issue":"3","key":"e_1_2_7_5_1","first-page":"23A","article-title":"Exploratory analysis of the association between donor sex and in\u2010hospital mortality in transfusion recipients","volume":"55","author":"Barty RL","year":"2015","journal-title":"Transfusion"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2015.12.022"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13537"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.3324"},{"key":"e_1_2_7_9_1","unstructured":"ZellerMP RuncimanRJR AhmedN et al. 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