{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T13:47:56Z","timestamp":1778680076159,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T00:00:00Z","timestamp":1543968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008394","name":"Natur og Univers, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["09\u2010069412"],"award-info":[{"award-number":["09\u2010069412"]}],"id":[{"id":"10.13039\/100008394","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004836","name":"Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["09\u2013069412"],"award-info":[{"award-number":["09\u2013069412"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The prevalence of iron depletion is high among premenopausal women who donate blood frequently. Studies in nondonor populations indicate that iron deficiency anemia is associated with an increased risk of low birth weight. This prompts concerns that iron deficiency induced by frequent blood donation might impair subsequent fetal development.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>The aim of this study was to assess whether prepregnancy donation intensity affects the birth weight of singletons born at term (gestational week 38 or later) to nulliparous female donors in Denmark. We identified 293,897 first live singleton births to Danish women between 1997 and 2012 with complete information on gestational age, birth weight, child sex, parental age, maternal smoking status during pregnancy, and parental education length and annual income. Linear regression analysis was applied, with birth weight as outcome, number of donations within the 3 years before pregnancy as the explanatory variable, and confounding variables as described.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Birth weight among children of low\u2010intensity donors (n = 22,120) was 12.6 g (95% confidence interval, 6.7\u201318.6) higher than nondonors (n = 268,253) after controlling for the above\u2010mentioned factors. The higher birth weight among low\u2010intensity donors can be explained by the healthy donor effect. In fully adjusted analyses, birth weight among children of high\u2010intensity donors (n = 3,524) was 20.2 g (95% confidence interval, 5.1\u201335.3 g) lower compared with low\u2010intensity donors. This reduced birth weight among high\u2010intensity donors compared to low\u2010intensity donors may reflect blood donation\u2013induced iron deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Our results show that high prepregnancy donation intensity is inversely associated with birth weight of singletons born at term to nulliparous women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15072","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T04:14:21Z","timestamp":1544069661000},"page":"995-1001","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Frequent blood donation and offspring birth weight\u2014a next\u2010generation association?"],"prefix":"10.1111","volume":"59","author":[{"given":"Andreas S.","family":"Rigas","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole B.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology N\u00e6stved Hospital  N\u00e6stved Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lise W.","family":"Th\u00f8rner","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margit H.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis M.","family":"Katz","sequence":"additional","affiliation":[{"name":"America's Blood Centers  Washington, DC Washington, DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaspar","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjell","family":"Titlestad","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustaf","family":"Edgren","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Cardiology S\u00f6dersjukhuset  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Rostgaard","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Erikstrup","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Hjalgrim","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut  Copenhagen Denmark"},{"name":"Department of Haematology Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Ullum","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,5]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"WHO. The world health report 2002 \u2010 reducing risks promoting healthy life.2002.https:\/\/www.who.int\/whr\/2002\/en\/cited: 09\u201027\u20102018"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12309"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1401038"},{"key":"e_1_2_9_5_1","unstructured":"WHO. Iron deficiency anemia: assesment prevention and control. A guide for programme managers. 2001. 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