{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T03:37:33Z","timestamp":1781840253952,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T00:00:00Z","timestamp":1544140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danish Council for Independent Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Blood donors have an increased risk of low hemoglobin (Hb) levels due to iron deficiency. Therefore, knowledge of genetic variants associated with low Hb could facilitate individualized donation intervals. We have previously reported three specific single\u2010nucleotide polymorphisms that were associated with ferritin levels in blood donors. In this study, we investigated the effect of these single\u2010nucleotide polymorphisms on Hb levels in 15,567 Danish blood donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>We studied 15,567 participants in the Danish Blood Donor Study. The examined genes and single\u2010nucleotide polymorphisms were 1) <jats:italic>TMPRSS6<\/jats:italic>, involved in regulation of hepcidin: rs855791; 2) <jats:italic>HFE<\/jats:italic>, associated with hemochromatosis: rs1800562 and rs1799945; 3) <jats:italic>BTBD9<\/jats:italic>, associated with restless leg syndrome: rs9357271; and 4) <jats:italic>TF<\/jats:italic>, encoding transferrin: rs2280673 and rs1830084. Associations with Hb levels and risk of Hb deferral were assessed in multivariable linear and logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The <jats:italic>HFE<\/jats:italic>,rs1800562 G\u2010allele and the <jats:italic>HFE<\/jats:italic> rs1799945 C\u2010allele were associated with lower Hb levels in men and women, and with an increased risk of Hb below 7.8 mmol\/L (12.5 g\/dL) in women. Only the rs1799945 C\u2010allele increased the risk of Hb below 8.4 mmol\/L (13.5 g\/dL) in men. In <jats:italic>TMPRSS6<\/jats:italic>, the rs855791 T\u2010allele was associated with lower Hb levels in both men and women, and with an increased risk of low Hb among women.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>With this study we demonstrate that <jats:italic>HFE<\/jats:italic> and <jats:italic>TMPRSS6<\/jats:italic> are associated with Hb levels and risk of Hb below the limit of deferral. Thus, genetic testing may be useful in a future assay for personalized donation intervals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15075","type":"journal-article","created":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T16:25:23Z","timestamp":1544199923000},"page":"226-231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Genetic factors influencing hemoglobin levels in 15,567 blood donors: results from the Danish Blood Donor Study"],"prefix":"10.1111","volume":"59","author":[{"given":"Erik","family":"S\u00f8rensen","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology Capital Region, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas S.","family":"Rigas","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Capital Region, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Didriksen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Capital Region, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristoffer S.","family":"Burgdorf","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Capital Region, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise W.","family":"Th\u00f8rner","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Capital Region, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole B.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Naestved Hospital  Naestved 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