{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T07:45:37Z","timestamp":1773042337634,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T00:00:00Z","timestamp":1544486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002244","name":"American Association of Blood Banks","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002244","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>ABO\u2010incompatible platelet transfusions are common, and transfusions with ABO\u2010incompatible plasma are increasing with the use of group A plasma and group O whole blood (WB) in emergencies. Many centers screen blood products for anti\u2010A and\/or anti\u2010B titers to help prevent hemolysis from ABO\u2010incompatible transfusions, yet titer methods and definition of high titers are not standardized.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>This international multicenter study collected data on anti\u2010A and anti\u2010B titer practices for plasma, apheresis platelet (AP), and WB units from January 2015 through December 2017 to determine the prevalence of high\u2010titer units using local definitions.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 87,701 plasma, AP and WB units were screened for high\u2010titer anti\u2010A and\/or anti\u2010B. High\u2010titer detection rates for group A plasma ranged 0%\u201313.6%; group A AP 2.7%\u20139.3%; group O AP 2.3%\u201365.7%; and group O WB 6.4%\u201320.7%. At the one center that collected group B AP, the high\u2010titer rate was 10.9%. High\u2010titer rates varied from month to month, as well as between years for a given month. There was no clear pattern of when high\u2010titer units were donated.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The prevalence of high\u2010titer plasma, AP, and WB units varies by titer method and local definition of high titer. Even at the lowest titer threshold of 50, a significant proportion of units had a high\u2010titer antibody, although the clinical relevance of this finding needs further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15083","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T04:51:01Z","timestamp":1544590261000},"page":"762-767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Seasonal variability is not observed in the rates of high anti\u2010A and anti\u2010B titers in plasma, apheresis platelet, and whole blood units tested by different methods"],"prefix":"10.1111","volume":"59","author":[{"given":"Sarah K.","family":"Harm","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Vermont Medical Center  Burlington Vermont"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark H.","family":"Yazer","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina B.","family":"Bub","sequence":"additional","affiliation":[{"name":"Hemotherapy and Cell Therapy Department Hospital Israelita Albert Einstein  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia S.","family":"Cohn","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota  Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eapen K.","family":"Jacob","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose M.","family":"Kutner","sequence":"additional","affiliation":[{"name":"Hemotherapy and Cell Therapy Department Hospital Israelita Albert Einstein  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Mair","sequence":"additional","affiliation":[{"name":"Blood Services \u2010 West Division American Red Cross  Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay S.","family":"Raval","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of North Carolina  Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth H.","family":"Shaz","sequence":"additional","affiliation":[{"name":"New York Blood Center  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyssa","family":"Ziman","sequence":"additional","affiliation":[{"name":"Wing\u2010Kwai and Alice Lee\u2010Tsing Chung Transfusion Service, Department of Pathology and Laboratory Medicine David Geffen School of Medicine, University of California Los Angeles  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8601-5438","authenticated-orcid":false,"given":"Nancy M.","family":"Dunbar","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Dartmouth\u2010Hitchcock Medical Center  Lebanon New Hampshire"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14139"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12329"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2006.00684.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02208.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001778"},{"key":"e_1_2_8_7_1","volume-title":"AABB. Standards for blood banks and transfusion services","year":"2018"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5858\/2008-132-1194-RTVIPO"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0351-OA"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14526"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14415"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0958-7578.2005.00598.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(88)90214-9"},{"key":"e_1_2_8_14_1","first-page":"13","article-title":"Smallpox vaccination and serum anti\u2010A levels","volume":"15","author":"Bourke GJ","year":"1965","journal-title":"Acta Genet Stat Med"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001432"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.5858\/2007-131-909-TOPCAP"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13948"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13592"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.15083","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.15083","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.15083","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.15083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T04:26:56Z","timestamp":1694665616000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.15083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,11]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/trf.15083"],"URL":"https:\/\/doi.org\/10.1111\/trf.15083","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,11]]},"assertion":[{"value":"2018-08-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}