{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:22:09Z","timestamp":1787865729656,"version":"build-2784847793"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>In the Brazilian Amazon, the filarial nematode <jats:italic>Mansonella ozzardi<\/jats:italic> co\u2010exists with malaria parasites and thick blood smear microscopy is considered the diagnostic gold standard. Transfusion of <jats:italic>M. ozzardi<\/jats:italic> microfilariae does not establish new infections, however microfilariae can survive approximately 2 years in blood\u2010recipients with unknown risk of pathology. Data on transfusion\u2010transmitted filariasis are lacking. This study investigated <jats:italic>M. ozzardi<\/jats:italic> parasitemias in blood donors from decentralized centers of \u201cFunda\u00e7\u00e3o Hematologia e Hemoterapia do Estado do Amazonas\/HEMOAM,\u201d Northern Brazil.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>Cross\u2010sectional investigation employing blood smear microscopy (n = 356) and qualitative nested\u2010<jats:italic>M. ozzardi<\/jats:italic>\u2010PCR (227 out of 356) in donor candidates from 19 hemocenters in interior\/rural municipalities of Amazonas state. FINDINGS: Participants were mostly young males. Positivity by microscopy was 7.9% (28 out of 356) and 23.8% by <jats:italic>M. ozzardi<\/jats:italic>\u2010PCR (54 out of 227). Parasitaemias were found in 16 out of 19 municipalities. In 54 <jats:italic>M. ozzardi<\/jats:italic>\u2010positives, 24 were ineligible; among 30 that donated, 27 were interdicted by seropositivity (22 anti\u2010HBc, 3 anti\u2010HBc + HBsAg, 1 Chagas+malaria, 1 VDRL). Seropositivty was higher in <jats:italic>M. ozzardi<\/jats:italic>\u2010PCR\u2010positives vs <jats:italic>M. ozzardi<\/jats:italic>\u2010PCR\u2010negatives (OR = 15.8, 95% CI 4.5\u201356.1, p &lt; 0.0001). Three <jats:italic>M. ozzardi<\/jats:italic> contaminated blood units were transfused, but no follow\u2010up information on the recipients is available.<\/jats:p><\/jats:sec><jats:sec><jats:title>MAIN CONCLUSIONS<\/jats:title><jats:p>Our study provides important baseline data on <jats:italic>M. ozzardi<\/jats:italic> among blood donors from the Brazilian Amazon. Further investigations in endemic areas are necessary to clarify possible association between <jats:italic>M. ozzardi<\/jats:italic> and other infections and also to elucidate whether there is any significant clinical effect upon transfusion of contaminated blood.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15101","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T15:25:57Z","timestamp":1545233157000},"page":"1044-1051","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Detection of <i>Mansonella ozzardi<\/i> among blood donors from highly endemic interior cities of Amazonas state, northern Brazil"],"prefix":"10.1111","volume":"59","author":[{"given":"Claudia M. M.","family":"Abrahim","sequence":"first","affiliation":[{"name":"HEMOAM, Departamento de Pesquisa Funda\u00e7\u00e3o Hospitalar de Hematologia e Hemoterapia do Estado do Amazonas  Manaus Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Py\u2010Daniel","sequence":"additional","affiliation":[{"name":"Departamento de Zoologia Universidade de Bras\u00edlia, Instituto de Ci\u00eancias Biol\u00f3gicas  Brasilia Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio L. B.","family":"Luz","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz Instituto Le\u00f4nidas e Maria Deane  Manaus Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson A.","family":"Fraiji","sequence":"additional","affiliation":[{"name":"HEMOAM, Departamento de Pesquisa Funda\u00e7\u00e3o Hospitalar de Hematologia e Hemoterapia do Estado do Amazonas  Manaus Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariane M. A.","family":"Stefani","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia, Microbiologia Patologia Geral e Parasitologia, Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, IPTSP, Universidade Federal de Goi\u00e1s UFG  Goi\u00e2nia Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/20477724.2016.1190544"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/RRTM.S125750"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/0074-0276130243"},{"key":"e_1_2_7_5_1","first-page":"281","article-title":"Estudo da patogenicidade da Mansonella ozzardi e da sintomatologia da mansonelose","volume":"2","author":"Batista D","year":"1960","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.5935\/0004-2749.19980011"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200011000-00011"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27492008000200007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-001266"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46651986000200007"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.13-0410"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1998.11813356"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2478(98)00133-3"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.07.007"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2007.03.009"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900257"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0b013e3283522c3d"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001890"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-1489-0_5"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006327"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2017.09.033"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1982.31.1142"},{"key":"e_1_2_7_23_1","first-page":"696","article-title":"A note on the survival of the microfilariae of Mansonella ozzardi","volume":"16","author":"Mazzotti L","year":"1957","journal-title":"Bull World Health Organ"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-248"},{"key":"e_1_2_7_25_1","first-page":"849","article-title":"Sobre a incid\u00eancia de fil\u00e1rias humanas em Manaus, Estado do Amazonas","volume":"2","author":"Deane MP","year":"1949","journal-title":"Rev Serv Esp Saude Publ"},{"key":"e_1_2_7_26_1","first-page":"16","article-title":"Mansonella ozzardi entre \u00edndios Ticunas do estado do Amazonas","volume":"84","author":"Moraes MA","year":"1978","journal-title":"Brasil Bol Oficina Sanit Panam"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0044-59672007000200010"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1979.28.991"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762009000100012"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0031-2012"},{"key":"e_1_2_7_31_1","unstructured":"World Health Organization. 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