{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:49:21Z","timestamp":1790696961144,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007459","name":"Ragnar S\u00f6derbergs stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007231","name":"Cancerf\u00f6reningen i Stockholm","doi-asserted-by":"publisher","award":["111602"],"award-info":[{"award-number":["111602"]}],"id":[{"id":"10.13039\/501100007231","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012538","name":"Swedish Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012538","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003514","name":"Kommunfullm\u00e4ktige, Stockholms Stad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003514","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Platelet refractoriness due to HLA immunization represents a problem in transfusion management of thrombocytopenic hematology patients. Refractory patients can be managed by HLA\u2010selected platelet transfusions, but the optimal matching strategy is debated and how the degree of HLA mismatch influences transfusion outcome is poorly studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY DESIGN AND METHODS<\/jats:title>\n                    <jats:p>\n                      We studied 32 hematology patients who received 142 matched platelet units between 2007 and 2016. Four matching strategies were compared: 1) genomic HLA typing at the two digit level, performed using polymerase chain reaction\u2013sequence\u2010specific oligonucleotide probing; 2) serologic \u201ceplet score\u201d calculated using HLAMatchmaker; 3) cross\u2010matching using lymphocyte cytotoxicity; and 4) matching based on donor\u2010specific antibody (DSA) specificity, determined using Luminex. A 1\u2010hour corrected count increment (CCI) of more than 7.5 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      \/L was considered a successful response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Selection of platelets with either a complete HLA match or an acceptable HLA mismatch based on genomic typing and DSA information, each predicted 86% successful transfusion responses. For HLA\u2010mismatched transfusions, the eplet score correlated with CCI and the fraction of successful transfusions, but less well compared to DSA matching. Cytotoxic crossmatching was least predictive. For transfusions across one to four DSAs, the antibody reaction strength correlated with the 1\u2010hour CCI, but many transfusions were successful despite the presence of DSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>A complete HLA\u2010A and \u2010B match or an acceptable mismatch based on DSA should guide identification of donors. Still, transfusions across DSAs are often successful, emphasizing that the presence of DSA is necessary but not sufficient for platelet clearance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.15108","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T16:41:32Z","timestamp":1545410492000},"page":"945-952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["HLA\u2010selected platelets for platelet refractory patients with HLA antibodies: a single\u2010center experience"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0378-3322","authenticated-orcid":false,"given":"Cecilia","family":"Karlstr\u00f6m","sequence":"first","affiliation":[{"name":"Center for Hematology and Regenerative Medicine (HERM), Department of Medicine Huddinge Karolinska Institutet  Stockholm Sweden"},{"name":"Hematology Center Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiina","family":"Linjama","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service Histocompatibility Laboratory  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustaf","family":"Edgren","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Cardiology  S\u00f6dersjukhuset, Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouni","family":"Lauronen","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service Histocompatibility Laboratory  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agneta","family":"Wikman","sequence":"additional","affiliation":[{"name":"Clinical Immunology and Transfusion Medicine Karolinska University Hospital and Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9233-626X","authenticated-orcid":false,"given":"Petter","family":"H\u00f6glund","sequence":"additional","affiliation":[{"name":"Center for Hematology and Regenerative Medicine (HERM), Department of Medicine Huddinge Karolinska Institutet  Stockholm Sweden"},{"name":"Clinical Immunology and Transfusion Medicine Karolinska University Hospital and Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01799.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2017.08.015"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.1999.7610001.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13597"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199712253372601"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02703.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12409"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01837.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1987.27587320531.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-196811000-00006"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(02)00382-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-032193"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904084"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V81.12.3428.3428"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2007.1.172"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1927.10502953"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471667196.ess5050.pub2"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1959.tb00346.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2006.10.003"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2724"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12412"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12921"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14316"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12411"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02206.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13350"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02644.x"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.15108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.15108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T02:08:33Z","timestamp":1694657313000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.15108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,21]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1111\/trf.15108"],"URL":"https:\/\/doi.org\/10.1111\/trf.15108","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,21]]},"assertion":[{"value":"2018-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}