{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:22:01Z","timestamp":1781756521697,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Do prescription drugs with anti\u2010inflammatory properties such as nonsteroidal anti\u2010inflammatory drugs (NSAIDs), corticosteroids, and statins increase the risk of postoperative bleeding measured with RBC transfusion in elderly hip fracture surgery patients?<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY DESIGN AND METHODS<\/jats:title>\n                    <jats:p>Using the Danish Multidisciplinary Hip Fracture Database, 74,791 patients aged 65 years or older with surgery\u2010treated hip fracture were identified during 2005\u20132016, and their use of NSAIDs, corticosteroids, and statins was ascertained. For each drug, patients were categorized as nonusers (no prescription \u2264365 days prior to surgery), former users (one prescription 91\u2013365 days), and current users (one prescription \u226490 days). Information on surgical treatment, transfusion, other medication and comorbidities were collected using Danish nationwide registries. A log\u2010binomial model was used to estimate relative risks for RBC transfusion within 7 days of surgery and corresponding 95% confidence intervals. Adjustments were made for patient\u2010 and surgery\u2010related factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Former and current users of NSAIDs, corticosteroids, and statins accounted for 22%, 10%, and 24%, respectively. Current users of NSAIDs had an increased adjusted relative risk of transfusion (1.07; confidence interval, 1.04\u20131.10) compared to nonusers. There was no association between current users of corticosteroids and statins and risk of transfusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>NSAID use within 90 days of a hip fracture surgery was associated with an increased risk of RBC transfusion. Thus, current use of NSAIDs can be associated with an increased risk of postoperative bleeding, but we cannot rule out the influence of confounding.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.15110","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T22:58:47Z","timestamp":1546642727000},"page":"935-944","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of preadmission anti\u2010inflammatory drug use on the risk of RBC transfusion in elderly hip fracture patients: a Danish nationwide cohort study, 2005\u20132016"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7708-8536","authenticated-orcid":false,"given":"Eva N.","family":"Glassou","sequence":"first","affiliation":[{"name":"University Clinic for Hand, Hip and Knee Surgery, Regional Hospital West Jutland, Aarhus University  Holstebro Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nickolaj","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjarne K.","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Erikstrup","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben B.","family":"Hansen","sequence":"additional","affiliation":[{"name":"University Clinic for Hand, Hip and Knee Surgery, Regional Hospital West Jutland, Aarhus University  Holstebro Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alma B.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453670903316835"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-012-1964-3"},{"key":"e_1_2_8_4_1","unstructured":"Dansk Tv\u00e6rfagligt Register for Hoften\u00e6re L\u00e5rbensbrud(2016). Annual report 2016 [cited 2017 Dec 15]. Available from:https:\/\/www.sundhed.dk\/sundhedsfaglig\/kvalitet\/kliniske-kvalitetsdatabaser\/akutte-sygdomme\/hoftebrud-nip\/."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3594-7"},{"key":"e_1_2_8_6_1","unstructured":"Dansk Transfusionsdatabase(2015). Annual report 2015 [cited 2017 Dec 15]. Available from:https:\/\/www.sundhed.dk\/sundhedsfaglig\/kvalitet\/kliniske-kvalitetsdatabaser\/specifikke-procedurer\/transfusionsdatabase\/."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03015766"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000217920.48559.D8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000153935.18997.14"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-10-167"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000173253.59827.7b"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-013-1795-7"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1503\/cjs.030413"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1462"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0306-5251.2001.01220.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)00941-X"},{"key":"e_1_2_8_17_1","first-page":"287","article-title":"Anti\u2010inflammatory and antithrombotic effects of statins in the management of coronary artery disease","volume":"48","author":"Undas A","year":"2002","journal-title":"Clin Lab"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2012.42.9.592"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzh031"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afw225"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9930-3"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S17901"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S37587"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S129785"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S59156"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.96B4.33209"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2014.942586"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2014.11.029"},{"key":"e_1_2_8_30_1","first-page":"375","article-title":"Preoperative factors associated with red blood cell transfusion in hip fracture patients","author":"Madsen CM","year":"2013","journal-title":"Arch Orthop Trauma Surg"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2015.1006980"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2015.03.022"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-016-0587-5"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.15110","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.15110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T02:08:20Z","timestamp":1694657300000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.15110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,4]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1111\/trf.15110"],"URL":"https:\/\/doi.org\/10.1111\/trf.15110","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.734767368.793555695","asserted-by":"object"}]},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,4]]},"assertion":[{"value":"2018-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}