{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:41:47Z","timestamp":1790718107364,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Platelet inventory constraints can result in minor ABO incompatibility and possible hemolysis. The aims of this study were to determine the reduction of isoagglutinin in titers of platelets stored in additive solution (PAS) and compare its safety, efficiency, and cost\u2010effectiveness with full\u2010volume and plasma\u2010reduced platelets.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>Isoagglutinin titers were performed in paired whole blood donor samples and apheresis platelets collected in PAS (PAS\u2010PLT) aliquot samples by the tube method.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 149 pairs of donor\/platelet samples were tested: 75 group O, 59 group A, and 15 group B. For group O donor samples, the median anti\u2010A IgG and IgM were 64 and 16, respectively, and the median anti\u2010B IgG and IgM were 64 and 16, respectively. For group O PAS\u2010PLT samples the mean anti\u2010A IgG and IgM, and anti\u2010B IgG and IgM were 32 and 8, and 16 and 8, respectively. For group A donor samples, the mean anti\u2010B IgG and IgM was 8 in both cases; and both titers decreased to 2 in PAS\u2010PLT. For group B donor samples, mean anti\u2010A IgG and IgM was 16 in both cases; and both titers decreased to 4 in PAS\u2010PLT. PAS\u2010PLT demonstrated a net reduction in cost and improved efficiency when compared to plasma reduction. The use of PAS\u2010PLT resulted in a 40% reduction of allergic transfusion reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The use of PAS decreases plasma isoagglutinin titers, transfusion reactions, and is cost\u2010effective when compared to routine plasma reduction as a strategy to mitigate hemolysis risk from minor incompatible platelet transfusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15138","type":"journal-article","created":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T07:29:23Z","timestamp":1545982163000},"page":"1246-1251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Evaluating safety and cost\u2010effectiveness of platelets stored in additive solution (PAS\u2010F) as a hemolysis risk mitigation strategy"],"prefix":"10.1111","volume":"59","author":[{"given":"Monica B.","family":"Pagano","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Division of Transfusion Medicine University of Washington  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brennan L.","family":"Katchatag","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Division of Transfusion Medicine Harborview Medical Center  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Khoobyari","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Division of Transfusion Medicine University of Washington  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Van Gerwen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Division of Transfusion Medicine University of Washington  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Division of Transfusion Medicine Harborview Medical Center  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Rebecca Haley","sequence":"additional","affiliation":[{"name":"Bloodworks Northwest  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry B.","family":"Gernsheimer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology University of Washington  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8596-4420","authenticated-orcid":false,"given":"John R.","family":"Hess","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Division of Transfusion Medicine Harborview Medical Center  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan A.","family":"Metcalf","sequence":"additional","affiliation":[{"name":"ARUP University of Utah  Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12045"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.03290.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.5858\/2007-131-909-TOPCAP"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03574.x"},{"key":"e_1_2_7_6_1","first-page":"139","article-title":"ABO incompatibility and hematopoietic stem cell transplantation outcomes","volume":"11","author":"Vaezi M","year":"2017","journal-title":"Int J Hematol Oncol Stem Cell 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