{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:26:00Z","timestamp":1787934360541,"version":"build-2784847793"},"reference-count":15,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T00:00:00Z","timestamp":1555113600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Hemorrhage is the leading cause of death on the battlefield. Damage control resuscitation guidelines in the US military recommend whole blood as the preferred resuscitation product. The Armed Services Blood Program (ASBP) has initiated low\u2010titer group O whole blood (LTOWB) production and predeployment donor screening to make whole blood more available to military forces.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>ASBP donor centers updated procedures and labeling for LTOWB production. Donors are screened according to US Food and Drug Administration regulations and standard operating procedures. Group O donors are tested for anti\u2010A and anti\u2010B titer levels. Additionally, military personnel notified for pending deployment coordinate with their local ASBP donor center to complete whole blood donor prescreening. The process consists of completing a donor history questionnaire, processing of blood samples for blood group and infectious disease testing, and titer determination for group O personnel.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Since March 2016, 7940 LTOWB units have been manufactured at ASBP donor centers and shipped in support of combat operations. Additionally, ASBP donor centers have screened several thousand service members before deployment. From these screenings, the donor low titer rate was 68% and infectious disease reactive test rate was extremely low (\u22640.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Whole blood is now the preferred blood product for resuscitation of combat trauma patients. The ASBP partnered with combat forces to screen personnel before deployment. Additionally, LTOWB is manufactured and shipped in support of combat operations. These efforts are expanding the availability of LTOWB for the warfighter.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15165","type":"journal-article","created":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T18:54:13Z","timestamp":1555181653000},"page":"1453-1458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Lifeline for the front lines: blood products to support the warfighter"],"prefix":"10.1111","volume":"59","author":[{"given":"Audra L.","family":"Taylor","sequence":"first","affiliation":[{"name":"Armed Services Blood Program Defense Health Agency  Falls Church Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason B.","family":"Corley","sequence":"additional","affiliation":[{"name":"Army Blood Program US Army Medical Command  JBSA\u2010Fort Sam Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Swingholm","sequence":"additional","affiliation":[{"name":"Army Blood Program US Army Medical Command  JBSA\u2010Fort Sam Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie A.","family":"Sloan","sequence":"additional","affiliation":[{"name":"Department of Pathology Womack Army Medical Center  Fort Bragg North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Harry","family":"McDonald","sequence":"additional","affiliation":[{"name":"U.S. Army Institute of Surgical Research  JBSA\u2010Fort Sam Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose F.","family":"Quesada","sequence":"additional","affiliation":[{"name":"Department of Defense Medical Education &amp; Training Campus  JBSA\u2010Fort Sam Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Pathology Landstuhl Regional Medical Center  Landstuhl Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Ceballos","sequence":"additional","affiliation":[{"name":"432<sup>nd<\/sup> Medical Detachment (Blood Support)  Fort Bragg North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3182755dcc"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.15097"},{"key":"e_1_2_8_4_1","unstructured":"ButlerFK HolcombJ ShackelfordSA et al. Joint Trauma System Committee Guidelines Tactical Combat Casaulty Care Guidelines. Retrieved 2018 Dec. from Joint Trauma System:http:\/\/jts.amedd.army.mil\/index.cfm\/committees\/cotccc\/guidelines."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/usy112"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/usy120"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000150"},{"key":"e_1_2_8_8_1","unstructured":"NeelS.Vietnam Studies Medical Support of the U.S. Army in Vietnam 1965\u20101970.http:\/\/history.amedd.army.mil\/booksdocs\/vietnam\/medicalsupport\/chapter9.html#table9. Department of the Army 1973. Accessed Aug 15 2018."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13501"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001778"},{"key":"e_1_2_8_11_1","unstructured":"Army Blood Program ABSOP B.200 ASBP 572 Blood Donation Record Review. 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