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In a previous study, we saw that inhibition of the CD40\/CD40L complex allowed restoration of ALI lesions in an experimental mouse model.<\/jats:p><\/jats:sec><jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>This study focused on pancreas\u2010associated injury development during experimental ALI pathogenesis and its limitation through CD40\/CD40L complex inhibition.<\/jats:p><\/jats:sec><jats:sec><jats:title>MATERIALS AND METHODS<\/jats:title><jats:p>An ALI mouse model was established through intraperitoneal lipopolysaccharide and intravenous anti\u2013major histocompatibility complex class I monoclonal antibody injection. Preemption of lesions was achieved with intravenous injection of neutralizing anti\u2010CD40L monoclonal antibody 30\u2009minutes before the trigger, that is, anti\u2013major histocompatibility complex class I monoclonal antibody administration. Histology and immunoassay analyses were used to evaluate pancreatic lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>ALI development induced significant degradation of the lungs and pancreas and was associated with pancreatic lesions. Different scores were established showing more severe injury to the pancreas in ALI conditions; however, injury was significantly reduced through CD40\/CD40L complex inhibition.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>This study supports the idea that several organs are exposed during ALI development, and particularly when such experimental ALI aims at mimicking transfusion\u2010associated ALI; nevertheless, preventive treatment inhibiting CD40\/CD40L (sCD40L) complex formation provides protection from lung disease as well as disease of other organs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15206","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T07:58:06Z","timestamp":1550649486000},"page":"1090-1101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Inhibition of the CD40\/CD40L complex protects mice against ALI\u2010induced pancreas 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