{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:56:44Z","timestamp":1780365404268,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T00:00:00Z","timestamp":1551052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Jiangsu Province's Key Provincial Talents Program","award":["ZDRCA2016013"],"award-info":[{"award-number":["ZDRCA2016013"]}]},{"name":"National Natural Science Funding of China","award":["81170181"],"award-info":[{"award-number":["81170181"]}]},{"name":"the Priority Academic Program Development of Jiangsu Higher Education Institutes","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Reversal of antiplatelet therapy is desirable in patients presenting with life\u2010threatening bleeding or requiring urgent surgery. This study aimed to examine ticagrelor reversal using donor platelets and to explore the effects of residual ticagrelor on donor platelets.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>In Cohort 1, 16 healthy subjects were treated with ticagrelor 90\u2009mg twice daily alone or in combination with aspirin 100\u2009mg once daily for 7 days followed by single blood sampling for preparation of platelet\u2010rich plasma. An additional 16 healthy subjects served as controls. In Cohort 2, 16 healthy subjects were treated with ticagrelor 90\u2009mg twice daily or clopidogrel 75\u2009mg once daily for 7 days followed by serial blood samplings for preparation of platelet\u2010poor plasma (PPP). An additional 16 healthy subjects served as controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In Cohort 1, inhibition of adenosine diphosphate\u2013induced platelet aggregation (PL<jats:sub>ADP<\/jats:sub>) by ticagrelor could not be fully reversed by mixing with up to 90% control platelets, whereas inhibition of arachidonic acid\u2013induced platelet aggregation by aspirin was fully reversed with the addition of 60% control platelets. In Cohort 2, 10% PPP obtained from ticagrelor\u2010treated subjects reduced PL<jats:sub>ADP<\/jats:sub> from 74% to 40% at 2 hours, 72% to 58% at 6 hours, and 73% to 59% at 10 hours, while 10% or 20% PPP obtained from clopidogrel\u2010treated subjects did not inhibit PL<jats:sub>ADP<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The antiplatelet effect of ticagrelor cannot be fully reversed by donor platelets, which could be explained by the presence of active drug. The effect of residual drug on donor platelets appears to be evident for at least 10 hours after ticagrelor ingestion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15219","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T05:46:30Z","timestamp":1551159990000},"page":"1850-1856","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Reversal of the antiplatelet effect of ticagrelor by simulated platelet transfusion"],"prefix":"10.1111","volume":"59","author":[{"given":"Shuhua","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"},{"name":"Department of Cardiology The Second People's Hospital of Lianyungang  Lianyungang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"},{"name":"Department of Cardiology Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianlian","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"},{"name":"Department of Geriatrics The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University  Changzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of 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