{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T17:17:55Z","timestamp":1780420675410,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,3]],"date-time":"2019-03-03T00:00:00Z","timestamp":1551571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007605","name":"Aarhus Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008392","name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Blood donors are at increased risk of developing iron deficiency, and several studies have recommended iron supplementation for this group. The aim of this study was to investigate the effect of oral iron supplementation on risk of infections among healthy blood donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>We included 82,062 participants from the Danish Blood Donor Study who completed a questionnaire on health\u2010related items including use of oral iron supplementation. Infection outcomes were ascertained by using ICD\u201010 codes in the Danish National Patient Register and Anatomical Therapeutic Chemical codes in the Danish Prescription Register. Multivariable Cox proportional hazards analysis was used as the statistical model. Risk estimates are presented as crude hazard ratios (HRs) with 95% confidence intervals (CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>During 19,978 person\u2010years of observation, 6983 donors redeemed at least one prescription of antimicrobials. Similarly, during 19,829 person\u2010years of observation, 242 donors were treated for infection at a hospital. Use of oral iron supplementation was not associated with redeemed prescriptions of antimicrobials in any strata: premenopausal women\u2014HR 1.00, 95% CI 0.91\u20101.10; postmenopausal women\u2014HR\u20091.07, 95% CI 0.87\u20101.32; and men\u2014HR\u20091.01, 95% CI 0.84\u20101.21. In addition, use of oral iron supplementation was not associated with risk of hospital\u2010based treatment for infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>In a large cohort of blood donors, use of oral iron supplementation was not associated with subsequent short\u2010term risk of infection. These findings are important to help understanding the safety of using oral iron supplementation among blood donors and the general population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15221","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T07:31:40Z","timestamp":1551684700000},"page":"2030-2038","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Oral iron supplementation is not associated with short\u2010term risk of infections: results from the Danish Blood Donor Study"],"prefix":"10.1111","volume":"59","author":[{"given":"Kathrine Agerg\u00e5rd","family":"Kaspersen","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khoa Manh","family":"Dinh","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Mikkelsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel Steen","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise Tornvig","family":"Erikstrup","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole Birger","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Naestved Hospital  Naestved Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Hjalgrim","sequence":"additional","affiliation":[{"name":"Epidemiology Research Statens Serum Institut  Copenhagen Denmark"},{"name":"Department of Hematology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Rigas","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaspar Rene","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Ullum","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Erikstrup","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,3]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"CD009532","article-title":"Oral or parenteral iron supplementation to reduce deferral, iron deficiency and\/or anaemia in blood donors","volume":"7","author":"Smith GA","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.119"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-10-8"},{"key":"e_1_2_9_5_1","first-page":"CD005095","article-title":"Enteral iron supplementation in preterm and low birth weight infants","volume":"3","author":"Mills RJ","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_6_1","unstructured":"Guideline: daily iron and folic acid supplementation in pregnant women [Internet]. 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