{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:34:18Z","timestamp":1780378458786,"version":"3.54.1"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:00:00Z","timestamp":1553731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Leukoreduction (LR) of platelet concentrate (PC) has evolved as the standard to mitigate risks of alloimmunization, clinical refractoriness, acute transfusion reactions (ATRs), and cytomegalovirus infection, but does not prevent transfusion\u2010associated graft\u2010versus\u2010host disease (TA\u2010GVHD). Amotosalen\u2013ultraviolet A pathogen reduction (A\u2010PR) of PC reduces risk of transfusion\u2010transmitted infection and TA\u2010GVHD. In vitro data indicate that A\u2010PR effectively inactivates WBCs and infectious pathogens.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>A sequential cohort study evaluated A\u2010PR without LR, gamma irradiation, and bacterial screening in hematopoietic stem cell transplant (HSCT) recipients. The first cohort received conventional PC (control) processed without LR, but with gamma irradiation and bacterial screening. The second cohort received A\u2010PR PC (test) processed without: LR, bacterial screening, or gamma irradiation. The primary efficacy outcome was the 1\u2010hour corrected count increment. The primary safety outcome was treatment\u2010emergent ATR. Secondary outcomes included clinical refractoriness, and 100\u2010day status for engraftment, TA\u2010GVHD, HSCT\u2010GVHD, infections, and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Mean corrected count increment (\u00d7 10<jats:sup>3<\/jats:sup>) of 33 test PC recipients was similar (18.9 \u00b1 8.8 vs. 16.6 \u00b1 8.4; p\u2009= 0.296) to that of 31 control PC recipients. Test recipients had a reduced, but nonsignificant, incidence of ATR (test\u2009= 9.1%, Control\u2009=\u200919.4%; p\u2009= 0.296). The frequencies of clinical refractoriness (0 of 33 vs. 4 of 31 patients) and refractory transfusions (6.6% vs. 19.3%) were lower in the test cohort (p\u2009= 0.05 and 0.02), respectively. No patient in either cohort had TA\u2010GVHD. Day 100 engraftment, HSCT\u2010GVHD, mortality, and infectious disease complications were similar between cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>This study indicated that A\u2010PR PC without LR, gamma irradiation, or bacterial screening is feasible for support of HSCT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15269","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T07:59:24Z","timestamp":1553759964000},"page":"1953-1961","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Transfusion of pathogen\u2010reduced platelet components without leukoreduction"],"prefix":"10.1111","volume":"59","author":[{"given":"Joycelyn","family":"Sim","sequence":"first","affiliation":[{"name":"Queen Mary Hospital and University of Hong Kong  Pok Fu Lam Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai Chiu","family":"Tsoi","sequence":"additional","affiliation":[{"name":"Hong Kong Red Cross Blood Transfusion Service  Yau Ma Tei Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheuk Kwong","family":"Lee","sequence":"additional","affiliation":[{"name":"Hong Kong Red Cross Blood Transfusion Service  Yau Ma Tei Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rock","family":"Leung","sequence":"additional","affiliation":[{"name":"Queen Mary Hospital and University of Hong Kong  Pok Fu Lam Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarence C. K.","family":"Lam","sequence":"additional","affiliation":[{"name":"Queen Mary Hospital and University of Hong Kong  Pok Fu Lam Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Koontz","sequence":"additional","affiliation":[{"name":"Cerus Corporation  Concord California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy Yingjie","family":"Liu","sequence":"additional","affiliation":[{"name":"Cerus Corporation  Concord California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Huang","sequence":"additional","affiliation":[{"name":"Cerus Corporation  Concord California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Cerus Corporation  Concord California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans J.","family":"Vermeij","sequence":"additional","affiliation":[{"name":"Cerus Corporation  Concord California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5132-2558","authenticated-orcid":false,"given":"Adonis","family":"Stassinopoulos","sequence":"additional","affiliation":[{"name":"Cerus Corporation  Concord California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8615-9869","authenticated-orcid":false,"given":"Laurence","family":"Corash","sequence":"additional","affiliation":[{"name":"Cerus Corporation  Concord California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert K. 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