{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:06:47Z","timestamp":1747188407196,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T00:00:00Z","timestamp":1554768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Predonation donor deferral is used to select donors with presumed lower risk for transfused transmitted infections. The contribution to blood safety from this practice has not been reported previously for Brazil.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>At four large Brazilian blood centers from September 2010 to March 2011, donors who were deferred due to responses on eligibility questions were invited to provide a blood sample to test for HIV, hepatitis C virus, hepatitis B virus, human T\u2010lymphotropic virus, syphilis, and <jats:styled-content style=\"fixed-case\"><jats:italic>Trypanosoma cruzi<\/jats:italic><\/jats:styled-content> and complete an audio computer\u2010assisted structured interview on risk behaviors.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Of 299,848 potential donors during the study period, 66,870 were deferred with 10,453 (15.6%) for high\u2010risk behaviors. Of those, 4860 (46.5%) were consecutively approached and 4013 (82.5%) participated. Disclosed risk behaviors by audio computer\u2010assisted structured interview included 4 or more sexual partners in the past 12\u2009months (15.0% of females [F] and 34.5% of males [M]), unprotected sex (62.0% F and 44.0% M), other high\u2010risk sexual exposure (85.0% F and 73.0% M), being a person who injects drugs (3.0% F and 10.0% M), and test\u2010seeking (17.0% F and 22.0% M). Eleven percent of deferred males reported male\u2010to\u2010male sex. Individuals who reported other high\u2010risk sexual exposure, sexual partner risk, or male\u2010to\u2010male sex had the highest frequency of confirmed HIV: 1.2, 0.7, and 0.7%, respectively. Individuals who reported male\u2010to\u2010male sex, sexual partner risk, test seeking, and unprotected sex had the highest frequency of confirmed syphilis: 3.8, 3.3, 2.4, and 2.0%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Donor deferral deters donation by individuals with risk behaviors and elevated rates of infectious disease markers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15286","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T16:53:55Z","timestamp":1554828835000},"page":"2334-2343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Does deferral for high\u2010risk behaviors improve the safety of the blood supply?"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5753-7026","authenticated-orcid":false,"given":"Thelma T.","family":"Gon\u00e7alez","sequence":"first","affiliation":[{"name":"Vitalant Research Institute  San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ester C.","family":"Sabino","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical e Departamento de Mol\u00e9stias Infecciosas e Parasit\u00e1rias da Faculdade de Medicina da Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanna","family":"Kaidarova","sequence":"additional","affiliation":[{"name":"Vitalant Research Institute  San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Barbara F.","family":"Carneiro\u2010Proietti","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Hemominas\/Hemocentro de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Miranda","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Hemominas\/Hemocentro de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Loureiro","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Hemope\/Hemocentro de Pernambuco  Recife Pernambuco Brazil"},{"name":"Pernambuco University  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Esther","family":"Lopes","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Hemorio\/Hemocentro do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar","family":"de Almeida\u2010Neto","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Pro\u2010Sangue\/ Hemocentro de S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Faculdade de Medicina da Universidade de S\u00e3o Paulo Disciplina Ci\u00eancias M\u00e9dicas  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen S.","family":"Schlumpf","sequence":"additional","affiliation":[{"name":"George Washington University  Washington DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Wright","sequence":"additional","affiliation":[{"name":"Westat, Inc.  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