{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:27Z","timestamp":1787016087434,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T00:00:00Z","timestamp":1585872000000},"content-version":"am","delay-in-days":366,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:00:00Z","timestamp":1554249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000006","name":"Office of Naval Research","doi-asserted-by":"publisher","award":["G1505"],"award-info":[{"award-number":["G1505"]}],"id":[{"id":"10.13039\/100000006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Hemorrhage remains the primary cause of preventable death in civilian and military trauma. The Committee on Tactical Combat Casualty Care recommends prehospital (PH) resuscitation with whole blood (WB). However, 6% hetastarch in lactated electrolyte (HEX) and crystalloids are more commonly available and used for PH resuscitation in military and civilian environments, respectively. The mechanistic benefits of PH WB resuscitation have not been well studied and remain to be elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY DESIGN AND METHODS<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the differences in simulated PH WB and HEX resuscitation, specifically with regards to coagulation, physiologic, and metabolic outcomes to better elucidate the mechanistic benefits of WB. In a randomized study, the physiologic, coagulation, and metabolic responses to simulated PH WB (n\u2009=\u200912) or HEX (n\u2009=\u200912) were evaluated in a nonhuman primate model of severe polytraumatic hemorrhagic shock.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Notable findings included 1) equivalence of shock reversal between simulated PH WB and HEX treatment groups as determined by hemodynamics and base deficit and 2) prevention of coagulopathy at simulated hospital arrival with initial WB resuscitation as determined by viscoelastic and plasmatic coagulation assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>The major benefit of WB, as compared to HEX, in simulated PH resuscitation appears to be prevention of coagulopathy at hospital arrival. Both fluids effectively reversed shock in this model, implying that efficacious provision preload (cardiac output support and hence oxygen delivery) and coagulation proteins (prevention of coagulopathy) are mechanisms underlying WB's effectiveness in early resuscitation of hemorrhagic shock.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.15294","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T10:52:54Z","timestamp":1554288774000},"page":"2238-2247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Prehospital whole blood resuscitation prevents coagulopathy and improves acid\u2013base status at hospital arrival in a nonhuman primate hemorrhagic shock model"],"prefix":"10.1111","volume":"59","author":[{"given":"Forest R.","family":"Sheppard","sequence":"first","affiliation":[{"name":"Naval Medical Research Unit San Antonio  JBSA\u2010Ft. Sam Houston Texas"},{"name":"Maine Medical Center  Portland Maine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"United States Army Institute of Surgical Research  JBSA\u2010Ft. Sam Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Cap","sequence":"additional","affiliation":[{"name":"United States Army Institute of Surgical Research  JBSA\u2010Ft. Sam Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leasha J.","family":"Schaub","sequence":"additional","affiliation":[{"name":"Naval Medical Research Unit San Antonio  JBSA\u2010Ft. Sam Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni R.","family":"Macko","sequence":"additional","affiliation":[{"name":"Naval Medical Research Unit San Antonio  JBSA\u2010Ft. Sam Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob J.","family":"Glaser","sequence":"additional","affiliation":[{"name":"Naval Medical Research Unit San Antonio  JBSA\u2010Ft. Sam Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3182755dcc"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318221147b"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3182754796"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318174e8bc"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000069184.82147.06"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3180324124"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ta.0000199545.06536.22"},{"key":"e_1_2_8_9_1","first-page":"121","volume-title":"Combat casualty care: lesson learned from OEF and OIF","author":"Savtisky E","year":"2012"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.55460\/DPOC-JWIY","article-title":"Fluid resuscitation for hemorrhagic shock in tactical combat casualty care: TCCC guidelines change 14\u201001\u2010\u20102 June 2014","volume":"14","author":"Butler FK","year":"2014","journal-title":"J Spec Oper Med"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12029"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.7205\/MILMED-D-14-00721"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000150"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13501"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13491"},{"key":"e_1_2_8_16_1","unstructured":"South Texas Blood and Tissue Center January 26 2018 (GLOBE NEWSWIRE): new type of blood transfusion on medical helicopters promises to transform trauma care improve survival rates."},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14869"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.15097"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000569"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000328"},{"key":"e_1_2_8_21_1","unstructured":"GivenM DunsonR.Multifunctional resuscitation fluid. 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