{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:52:05Z","timestamp":1790279525100,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CAMS Innovation Fund for Medical Sciences\uff08CIFMS\uff09","award":["2016-I2M-3-024"],"award-info":[{"award-number":["2016-I2M-3-024"]}]},{"name":"CAMS Innovation Fund for Medical Sciences\uff08CIFMS\uff09","award":["2017-I2M-1-009"],"award-info":[{"award-number":["2017-I2M-1-009"]}]},{"name":"the PUMC Youth Fund","award":["3332015121"],"award-info":[{"award-number":["3332015121"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>China has not yet incorporated routine human T\u2010lymphotropic virus (HTLV)\u20101\/2 blood donor screening, even though HTLV has been reported in the southeastern coastal region. This study was conducted to investigate the prevalence of HTLV in five major regions across of China.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>From January 2016 to December 2017, blood samples were collected in 20 blood centers located in different regions of China. These samples were screened for HTLV\u20101\/2 antibodies using enzyme\u2010linked immunosorbent assay (ELISA). If the test samples were reactive, the samples were confirmed with a western blot (WB) assay. If the results of WB were indeterminate, the donor was interviewed after a minimum lapse of 8 weeks. All follow\u2010up samples from donors were tested for anti\u2013HTLV\u20101\/2 with ELISA and WB.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>There were 875,453 donor samples tested for anti\u2013HTLV\u20101\/2 by ELISA. In all, 365 samples tested negative, 22 samples tested positive by WB, and 14 samples with HTLV status undetermined due to being lost to follow\u2010up. The prevalences were 11.09, 5.96, 3.16, 2.88 and 0.98 per 100,000 in Xiamen, Changsha, Beijing, Shenzhen, and Nanjing blood center, respectively. The prevalences were 0 per 100,000 for all 15 other blood centers. There was significant differences in the prevalence of HTLV in different regions of China (p\u2009= 0.0011).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>In China, HTLV\u20101 confirmed positive donors are mainly from southeastern coastal areas. It may be necessary to conduct HTLV screening in these areas to reduce the risk of transfusion\u2010transmitted HTLV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15309","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T14:27:50Z","timestamp":1555338470000},"page":"2361-2367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The prevalence of human T\u2010cell leukemia virus in blood donors in China"],"prefix":"10.1111","volume":"59","author":[{"given":"Ling","family":"Li","sequence":"first","affiliation":[{"name":"Clinical Transfusion Research Center Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College  Chengdu Sichuan China"},{"name":"Key Laboratory of Transfusion Adverse Reactions, CAMS  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanhai","family":"Ou","sequence":"additional","affiliation":[{"name":"Xiamen Blood Center  Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyin","family":"Huang","sequence":"additional","affiliation":[{"name":"Jiangsu Blood Center  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Anhui Blood Center  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Ge","sequence":"additional","affiliation":[{"name":"Beijing Blood Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Li","sequence":"additional","affiliation":[{"name":"Liaoning Blood Center  Shenyang Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Zeng","sequence":"additional","affiliation":[{"name":"Shenzhen Blood Center  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Zhou","sequence":"additional","affiliation":[{"name":"University of California, Berkeley  Berkeley California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"He","sequence":"additional","affiliation":[{"name":"Hefei Tian Yi Biotech Institute Co., Ltd.  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