{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:59:48Z","timestamp":1761490788092},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T00:00:00Z","timestamp":1555632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Launched in 2013, Canadian Blood Services' Cord Blood Bank (CBS' CBB) has built a high\u2010quality, ethnically diverse cord blood repository that aims to reduce ethnic disparity in accessing suitable units for transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS AND RESULTS<\/jats:title><jats:p>As of December 2016, 2000\u2009units have been banked. The self\u2010reported maternal ethnicity was 58% non\u2010Caucasian. Overall, 26% of units were classified as multi\u2010ethnicity with Caucasian (84%) most frequently observed in combination with Asian, First Nations (predominant indigenous peoples in Canada south of the Arctic Circle), or African ethnicity. Utilization scores that incorporate total nucleated and CD34+ cell counts in the CBS' CBB were associated with greater likelihood of utilization compared with the international inventory of units (p\u2009&lt; 0.05). The distribution of utilization scores was similar for Caucasians compared with non\u2010Caucasians (p\u2009&lt; 0.05). Using HLA genotypes of cord blood units and their mothers, we determined probable ethnic assignments for each haplotype using HaploStats (National Marrow Donor Program). Significant increases in HLA\u2010match likelihoods are predicted for all ethnicities as the inventory grows to its target of 10,000\u2009units and the gap in HLA\u2010match likelihoods for Caucasian and non\u2010Caucasian patients progressively declines.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The CBS' CBB inventory is predicted to have high HLA\u2010matching likelihoods across a broad spectrum of ethnic groups, improving access to high\u2010quality stem cell products for all patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15313","type":"journal-article","created":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T13:45:12Z","timestamp":1555681512000},"page":"2382-2388","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Reducing ethnic disparity in access to high\u2010quality HLA\u2010matched cord blood units for transplantation: analysis of the Canadian Blood Services' Cord Blood Bank inventory"],"prefix":"10.1111","volume":"59","author":[{"given":"David","family":"Allan","sequence":"first","affiliation":[{"name":"Ottawa Hospital Research Institute and Department of Medicine University of Ottawa  Ottawa Ontario"},{"name":"Canadian Blood Services' Cord Blood Bank  Ottawa Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Kiernan","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute and Department of Medicine University of Ottawa  Ottawa Ontario"},{"name":"Canadian Blood Services' Cord Blood Bank  Ottawa Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loren","family":"Gragert","sequence":"additional","affiliation":[{"name":"University of Tulane  New Orleans Louisiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Dibdin","sequence":"additional","affiliation":[{"name":"Canadian Blood Services' Cord Blood Bank  Ottawa Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Bartlett","sequence":"additional","affiliation":[{"name":"Canadian Blood Services' Cord Blood Bank  Ottawa Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd","family":"Campbell","sequence":"additional","affiliation":[{"name":"Canadian Blood Services' Cord Blood Bank  Ottawa Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Mostert","sequence":"additional","affiliation":[{"name":"Canadian Blood Services' Cord Blood Bank  Ottawa Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Halpenny","sequence":"additional","affiliation":[{"name":"Canadian Blood Services' Cord Blood Bank  Ottawa Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Ganz","sequence":"additional","affiliation":[{"name":"Canadian Blood Services' Cord Blood Bank  Ottawa Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Maiers","sequence":"additional","affiliation":[{"name":"National Marrow Donor Program  Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya","family":"Petraszko","sequence":"additional","affiliation":[{"name":"Canadian Blood Services' Cord Blood Bank  Ottawa Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Elmoazzen","sequence":"additional","affiliation":[{"name":"Canadian Blood Services' Cord Blood Bank  Ottawa Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1311707"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-018-0153-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2016.12.004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.07.007"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-506253"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14458"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/463031"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143440"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.03.006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12630"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240310000083"},{"key":"e_1_2_7_13_1","unstructured":"Safety of human cells tissues and organs for transplantation regulations (SOR\/2007\u2010118) Health Canada Government of Canada. Regulations were last amended on 2015\u201002\u201011. Available from:https:\/\/www.canada.ca\/en\/health-canada accessed 2019\u201004\u201015."},{"key":"e_1_2_7_14_1","volume-title":"Immigration and ethnocultural diversity in Canada","author":"Statistics Canada","year":"2011"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000345690"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13424"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2010.03.002"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2008.002741"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10561-016-9565-6"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2017.08.027"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.15313","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.15313","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.15313","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.15313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T21:57:02Z","timestamp":1694296622000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.15313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,19]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/trf.15313"],"URL":"https:\/\/doi.org\/10.1111\/trf.15313","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,19]]},"assertion":[{"value":"2019-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}