{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T18:23:25Z","timestamp":1789323805644,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T00:00:00Z","timestamp":1562716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001136","name":"Australian and New Zealand College of Anaesthetists","doi-asserted-by":"publisher","award":["Academic Enhancement Grant 2013"],"award-info":[{"award-number":["Academic Enhancement Grant 2013"]}],"id":[{"id":"10.13039\/501100001136","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Cryopreservation extends platelet (PLT) shelf life from 5 to 7\u2009days to 2 to 4\u2009years. However, only 73 patients have been transfused cryopreserved PLTs in published randomized controlled trials (RCTs), making safety data insufficient for regulatory approval.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>The Cryopreserved vs. Liquid Platelet (CLIP) study was a double\u2010blind, pilot, multicenter RCT involving high\u2010risk cardiothoracic surgical patients in four Australian hospitals. The objective was to test, as the primary outcome, the feasibility and safety of the protocol. Patients were allocated to study group by permuted block randomization, with patients and clinicians blinded by use of an opaque shroud placed over each study PLT unit. Up to 3\u2009units of cryopreserved or liquid\u2010stored PLTs were administered per patient. No other aspect of patient care was affected. Adverse events were actively sought.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 121 patients were randomized, of whom 23 received cryopreserved PLTs and 18 received liquid\u2010stored PLTs. There were no differences in blood loss (median, 715\u2009mL vs. 805\u2009mL at 24\u2009hr; difference between groups 90\u2009mL [95% CI, \u2013343.8 to 163.8\u2009mL], p = 0.41), but the Bleeding Academic Research Consortium criterion for significant postoperative hemorrhage in cardiac surgery composite bleeding endpoint occurred in nearly twice as many patients in the liquid\u2010stored group (55.6% vs. 30.4%, p = 0.10). Red blood cell transfusion requirements were a median of 3\u2009units in the cryopreserved group versus 4\u2009units with liquid\u2010stored PLTs (difference between groups, 1 unit [95% CI, \u20133.1 to 1.1 units]; p = 0.23). Patients in the cryopreserved group were more likely to be transfused fresh\u2010frozen plasma (78.3% vs. 27.8%, p = 0.002) and received more study PLT units (median, 2\u2009units vs. 1 unit; difference between groups, 1 unit [95% CI, \u20130.03 to 2.0 units]; p = 0.012). There were no between\u2010group differences in potential harms including deep venous thrombosis, myocardial infarction, respiratory function, infection, and renal function. No patient had died at 28\u2009days, and postoperative length of stay was similar in each group.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>In this pilot RCT, compared to liquid\u2010stored PLTs, cryopreserved PLTs were associated with no evidence of harm. A definitive study testing safety and hemostatic effectiveness is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15423","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T10:33:33Z","timestamp":1562754813000},"page":"2794-2804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["A randomized, controlled pilot clinical trial of cryopreserved platelets for perioperative surgical bleeding: the CLIP\u2010I trial <i>(Editorial, p. 2759)<\/i>"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1570-0707","authenticated-orcid":false,"given":"Michael C.","family":"Reade","sequence":"first","affiliation":[{"name":"Joint Health Command, Australian Defence Force  Canberra Australian Capital Territory Australia"},{"name":"University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3674-6934","authenticated-orcid":false,"given":"Denese C.","family":"Marks","sequence":"additional","affiliation":[{"name":"Australian Red Cross Blood Service  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1650-8939","authenticated-orcid":false,"given":"Rinaldo","family":"Bellomo","sequence":"additional","affiliation":[{"name":"Austin Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renae","family":"Deans","sequence":"additional","affiliation":[{"name":"University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Faulke","sequence":"additional","affiliation":[{"name":"The Prince Charles Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7012-2519","authenticated-orcid":false,"given":"John F.","family":"Fraser","sequence":"additional","affiliation":[{"name":"The Prince Charles Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9282-7093","authenticated-orcid":false,"given":"David J.","family":"Gattas","sequence":"additional","affiliation":[{"name":"Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8042-6084","authenticated-orcid":false,"given":"Anthony D.","family":"Holley","sequence":"additional","affiliation":[{"name":"University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David O.","family":"Irving","sequence":"additional","affiliation":[{"name":"Australian Red Cross Blood Service  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3303-4437","authenticated-orcid":false,"given":"Lacey","family":"Johnson","sequence":"additional","affiliation":[{"name":"Australian Red Cross Blood Service  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronwyn L.","family":"Pearse","sequence":"additional","affiliation":[{"name":"The Prince Charles Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4449-663X","authenticated-orcid":false,"given":"Alistair G.","family":"Royse","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Wong","sequence":"additional","affiliation":[{"name":"Australian Red Cross Blood Service  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Cryopreserved vs Liquid Platelet (CLIP) Investigators, the Australian and New Zealand College of Anaesthetists Clinical Trials Network, and the Australian and New Zealand Intensive Care Society Clinical Trials Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,10]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":""},{"key":"e_1_2_8_3_1","volume-title":"The 2016 annual SHOT report","author":"Bolton\u2010Maggs PH","year":"2017"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13778"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-6247.28066"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V43.1.131.131"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.00647.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2005.11.008"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12915"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12533"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168401"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cryobiol.2011.01.003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.2002.00229.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1999.39080880.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0041-1132.2005.04291.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2015.10.011"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14828"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13371"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03735.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14780"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(99)70483-6"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15177"},{"key":"e_1_2_8_23_1","first-page":"268","article-title":"Kryokonzervovan\u00e9 trombocyty v klinick\u00e9 praxi: srovn\u00e1vac\u00ed studie s nativn\u00edmi trombocyty","volume":"22","author":"Bohon\u011bk M","year":"2016","journal-title":"Transfuze Hematol"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12758"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/jcan.2002.29674"},{"key":"e_1_2_8_27_1","volume-title":"Patient Blood Management Guidelines Module 2 \u2010 Perioperative","year":"2012"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.5669"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002652"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707572"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2824.2012.01586.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-6247.162684"},{"key":"e_1_2_8_33_1","volume-title":"Guidelines for transfusion and immunohaematology laboratory practice","year":"2016"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.15423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.15423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.15423","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.15423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T02:24:37Z","timestamp":1694226277000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.15423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,10]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/trf.15423"],"URL":"https:\/\/doi.org\/10.1111\/trf.15423","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,10]]},"assertion":[{"value":"2018-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}