{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:06:59Z","timestamp":1747188419949,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Current American and Canadian guidelines recommend delaying live vaccine immunization by 5 to 6\u2009months after transfusion of red blood cells (RBCs) due to potential interference by serum antibodies. Due to lack of data, the recommendations may be unfounded and prevent valuable vaccination opportunities for children with frequent blood transfusions. The primary aim of this study was to determine measles, mumps, rubella (MMR) vaccine immunogenicity in patients chronically transfused with RBCs. A secondary aim was to quantify vaccine antibodies in RBC donations.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>MMR\u2010specific antibodies were quantified in 25 pediatric patients who received both doses of MMR vaccine while on a chronic RBC transfusion program (median, 6.6\u2009years after vaccination). MMR antibodies were also quantified in 30 samples of supernatants from RBC donations.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Immunity to each of the MMR components was 68% to 76%. In blood donors born before 1976 (pre\u2010MMR vaccine), 67% of MMR serologies in the supernatants of RBC donations were at the immune level versus 7% in blood donors born after 1976.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>This is the first study of the impact of RBC transfusions on MMR vaccine immunogenicity. Although lower than in the literature (immunity rates, \u226590%), the results show a high rate of immunogenicity of the MMR vaccine in chronically transfused patients. Additionally, results suggest that MMR antibody content in transfusions will continue to decrease with time. Weighing the risks and benefits of disease prevention in a vulnerable population, a reevaluation of immunization delays after RBC transfusions is called for.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15433","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T13:02:07Z","timestamp":1562245327000},"page":"2806-2811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Reevaluating immunization delays after red blood cell transfusion"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5059-1572","authenticated-orcid":false,"given":"Alexandra","family":"Zabeida","sequence":"first","affiliation":[{"name":"Department of Pediatrics Montreal Children's Hospital  Montreal Quebec Canada"},{"name":"McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc H.","family":"Lebel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics CHU Sainte\u2010Justine  Montreal Quebec Canada"},{"name":"University of Montreal  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Renaud","sequence":"additional","affiliation":[{"name":"Department of Pediatrics CHU Sainte\u2010Justine  Montreal Quebec Canada"},{"name":"University of Montreal  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Cloutier","sequence":"additional","affiliation":[{"name":"H\u00e9ma\u2010Qu\u00e9bec, Qu\u00e9bec City  Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Robitaille","sequence":"additional","affiliation":[{"name":"Department of Pediatrics CHU Sainte\u2010Justine  Montreal Quebec Canada"},{"name":"University of Montreal  Montreal Quebec Canada"},{"name":"H\u00e9ma\u2010Qu\u00e9bec  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,4]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Public Health Agency of Canada. Canadian immunization guide: part 1 \u2010 key immunization information [Internet]. Ottawa: Public Health Agency of Canada; updated Jan 24 2018 [cited 2018 Jun 7]. Available from:http:\/\/www.phac-aspc.gc.ca\/publicat\/cig-gci\/p01-10-eng.php."},{"key":"e_1_2_8_3_1","unstructured":"Canadian Pediatric Society.Immunization and vaccines [Internet]. Ottawa: Canadian Pediatric Society; updated May 14 2018 [cited 2018 Jun 7]. Available from:http:\/\/www.cps.ca\/issues-questions\/immunization."},{"key":"e_1_2_8_4_1","unstructured":"Direction de la protection de la sant\u00e9 publique Minist\u00e8re de la Sant\u00e9 et des Services sociaux du Qu\u00e9bec. Protocole d'immunisation du Qu\u00e9bec [Internet]. 7th ed. Quebec: Direction de la protection de la sant\u00e9 publique Minist\u00e8re de la Sant\u00e9 et des Services sociaux du Qu\u00e9bec; updated May 2 2018 [cited 2018 Jun 7]. Available from:http:\/\/www.msss.gouv.qc.ca\/professionnels\/vaccination\/protocole-d-immunisation-du-quebec-piq\/."},{"issue":"04","key":"e_1_2_8_5_1","first-page":"1","article-title":"Prevention of measles, rubella, congenital rubella syndrome, and mumps, 2013: summary recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"62","author":"McLean HQ","year":"2013","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(06)80114-9"},{"key":"e_1_2_8_7_1","unstructured":"MasonW TakahashiM SchneiderT.Persisting passively acquired measles antibody following gamma globulin therapy for Kawasaki disease and response to live virus vaccination [Abstract 311]. Presented at the 32nd meeting of the Interscience Conference on Antimicrobial Agents and Chemotherapy; Los Angeles CA; 1992."},{"key":"e_1_2_8_8_1","first-page":"585","article-title":"Effect of immune globulin on the response to trivalent oral poliovirus and yellow fever vaccinations","volume":"62","author":"Kaplan J","year":"1984","journal-title":"Bull World Health Organ"},{"key":"e_1_2_8_9_1","unstructured":"University of California Los Angeles Pathology Department. Blood product modifications: leukoreduction irradiation and washing. Los Angeles: University of California Los Angeles Pathology Department; updated Jun 2012 [cited 2018 Feb 8]. Available from:http:\/\/pathology.ucla.edu\/workfiles\/Education\/Transfusion%20Medicine\/2-6-Blood-Product-Modifications.pdf."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001721"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15846"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001518"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.11.105"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.05.046"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-0571"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1408.08048"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.113710"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/506363"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.15433","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.15433","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.15433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T02:23:08Z","timestamp":1694226188000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.15433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,4]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/trf.15433"],"URL":"https:\/\/doi.org\/10.1111\/trf.15433","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"type":"print","value":"0041-1132"},{"type":"electronic","value":"1537-2995"}],"subject":[],"published":{"date-parts":[[2019,7,4]]},"assertion":[{"value":"2019-02-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}