{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:27Z","timestamp":1787016087479,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Recipients of platelet transfusions with 1\u2010hour corrected count increments (1hCCIs) of 7.5 or less on two subsequent platelet transfusions with random platelets may benefit from human leukocyte antigen (HLA)\u2010matched platelet concentrates. We aimed to quantify the efficacy of HLA\u2010matched platelets concentrates expressed in 1hCCIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We performed a cohort study among consecutive refractory patients who received HLA\u2010matched platelet concentrates in the Netherlands between 1994 and 2017. We performed mixed\u2010model linear regression comparing 1hCCIs after HLA split\u2010antigen\u2013matched transfusions with 1hCCIs after HLA\u2010mismatched transfusions, adjusted for within\u2010patient correlations. A donor\u2010to\u2010patient match was categorized as a split\u2010match if all donor HLA\u2010A and \u2010B antigens were present in the patient as well; that is, donor and patient were HLA identical or compatible. Subgroup analyses were performed for patients with positive or negative HLA antibody screens. Finally, the additional effect of ABO mismatches on 1hCCIs was investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The 1hCCI after an HLA\u2010matched transfusion was 14.09 (95% reference interval, 1.13\u201029.89). This was 1.94 (95% confidence interval [CI], 0.74\u20103.15) higher than 1hCCI after HLA\u2010mismatched transfusions. In patients with negative HLA antibody screening tests, HLA matching did not affect 1hCCIs. Conditional on HLA matching, 1hCCIs decreased by 3.70 (95% CI, \u20105.22 to \u22122.18) with major ABO mismatches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Matched platelet concentrates yielded maximal 1hCCIs, whereas mismatched transfusions still resulted in adequate increments. There is no indication for HLA\u2010matched platelets in patients with negative antibody screens.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.15530","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T04:25:50Z","timestamp":1570767950000},"page":"3303-3307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["HLA\u2010matched platelet transfusions are effective only in refractory patients with positive HLA antibody screening"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1658-9257","authenticated-orcid":false,"given":"Aukje L.","family":"Kreuger","sequence":"first","affiliation":[{"name":"Center for Clinical Transfusion Research Sanquin Research  Leiden The Netherlands"},{"name":"Department of Clinical Epidemiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja B.U.","family":"M\u00e4kelburg","sequence":"additional","affiliation":[{"name":"Unit Transfusion Medicine Sanquin Blood Bank  Amsterdam The Netherlands"},{"name":"Department of Hematology University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.E.","family":"Somers","sequence":"additional","affiliation":[{"name":"Unit Transfusion Medicine Sanquin Blood Bank  Amsterdam The Netherlands"},{"name":"Department of Hematology Erasmus MC\u2010Daniel Den Hoed Cancer Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Tomson","sequence":"additional","affiliation":[{"name":"Unit Transfusion Medicine Sanquin Blood Bank  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo M. G.","family":"van de Watering","sequence":"additional","affiliation":[{"name":"Unit Transfusion Medicine Sanquin Blood Bank  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna G.","family":"van der Bom","sequence":"additional","affiliation":[{"name":"Center for Clinical Transfusion Research Sanquin Research  Leiden The Netherlands"},{"name":"Department of Clinical Epidemiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian G.J.","family":"van Kraaij","sequence":"additional","affiliation":[{"name":"Center for Clinical Transfusion Research Sanquin Research  Leiden The Netherlands"},{"name":"Unit Transfusion Medicine Sanquin Blood Bank  Amsterdam The Netherlands"},{"name":"Unit Donor Affairs Sanquin Blood Bank  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia M.","family":"Weller","sequence":"additional","affiliation":[{"name":"Unit Transfusion Medicine Sanquin Blood Bank  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2012.189209"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08227.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.1997.73301911.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14316"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2012.01852.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13597"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12175"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(17)30078-6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2017.1346471"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2014.11.004"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02273.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2724"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02602.x"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.15530","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.15530","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.15530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T18:24:56Z","timestamp":1693333496000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.15530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,11]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1111\/trf.15530"],"URL":"https:\/\/doi.org\/10.1111\/trf.15530","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,11]]},"assertion":[{"value":"2019-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}