{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:10:00Z","timestamp":1790655000203,"version":"4.1.0"},"reference-count":98,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>Developments during the past few years have resulted in multiple kinds of platelet products for transfusion. This involves different collection methods, containers, preservative solutions, modifications of storage temperatures and durations, and additional treatments such as pathogen reduction. Much experience has been obtained testing these processes in vitro to seek indications of in vivo effectiveness. Availability of an in vitro method that correlated with in vivo effectiveness would be extremely valuable for these different kinds of platelet products and as more innovation in platelet preparation occurs in the future. This report reviews the methods for in vitro platelet testing with a view to their in vivo implications and whether such testing could be helpful in projecting the clinical effectiveness of different platelet products.<\/jats:p>","DOI":"10.1111\/trf.15559","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T07:22:37Z","timestamp":1571815357000},"page":"3783-3793","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Platelet in vitro assays: their correspondence with their in vivo hemostatic potential"],"prefix":"10.1111","volume":"59","author":[{"given":"Gines","family":"Escolar","sequence":"first","affiliation":[{"name":"Department of Hemotherapy and Hemostasis, ICMHO Hospital Clinic of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8730-3981","authenticated-orcid":false,"given":"Jeffrey","family":"McCullough","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,23]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"CD009072","article-title":"Pathogen\u2010reduced platelets for the prevention of bleeding","volume":"7","author":"Estcourt LJ","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4443"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb03587.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12634"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14868"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1980.20581034500.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1993.33994025028.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.4.1121"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1991.31591263195.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2009.07.015"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12307"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.7.2353"},{"key":"e_1_2_9_14_1","first-page":"39","article-title":"The use of fluorescence flow cytometry in the characterization of Bernard\u2010Soulier syndrome and Glanzmann\u02bcs thrombasthenia","volume":"74","author":"Fabris F","year":"1989","journal-title":"Haematologica"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V59.3.563.563"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12243"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1983.23383224896.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1986.26186124039.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1996.36296181924.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2006.00761.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00895.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2011.03.003"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2015.05.002"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1990.tb00849.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12325"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13345"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14962"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13630"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1994.tb00271.x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03323.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12232"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1995.35295125733.x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.2002.00172.x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1993.33393174443.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00979.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12378"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409083311001"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-3886(96)00084-7"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000203359"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12203"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2013-0680-OA"},{"key":"e_1_2_9_42_1","first-page":"635","article-title":"Development of giant granules in platelets during prolonged storage","volume":"101","author":"White JG","year":"1980","journal-title":"Am J Pathol"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537100600757695"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1975.15576082215.x"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15356"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-4310(95)80031-X"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.1974.tb04504.x"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1987.tb01304.x"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-3886(99)00022-3"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02819.x"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjh.2016.0049"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613823"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537109509078469"},{"key":"e_1_2_9_54_1","first-page":"112","article-title":"Cytoskeletal reorganization after preparation of platelet concentrates, using the buffy coat method, and during their storage","volume":"83","author":"Estebanell E","year":"1998","journal-title":"Haematologica"},{"key":"e_1_2_9_55_1","first-page":"144","article-title":"Improved maintenance of platelet in vivo viability during storage when using a synthetic medium with inhibitors","volume":"119","author":"Holme S","year":"1992","journal-title":"J Lab Clin Med"},{"key":"e_1_2_9_56_1","first-page":"401","article-title":"Filtered platelet concentrates from pooled buffy coats show comparable storage lesions when stored for 9 d at 20\u201024 degrees C or when supplemented with thromboSol at 2\u20106 degrees C","volume":"64","author":"Schaller M","year":"2000","journal-title":"EurJHaematol"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12566"},{"key":"e_1_2_9_58_1","first-page":"255","article-title":"In vitro evaluation of pathogen\u2010inactivated buffy coat\u2010derived platelet concentrates during storage: psoralen\u2010based photochemical treatment step\u2010by\u2010step","volume":"13","author":"Abonnenc M","year":"2015","journal-title":"Blood Transfus"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14462"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1661194"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-01-199414"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12416"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.01034.x"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1988.28288179014.x"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1990.30190117623.x"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1995.35495216076.x"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.04350.x"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02914.x"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2009.01283.x"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12237"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.21037\/aob.2018.12.03"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106504"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02821.x"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00702.x"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/35092573"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2000.40050535.x"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1992.tb04570.x"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00484.x"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13544"},{"key":"e_1_2_9_80_1","first-page":"370","article-title":"Effects of storage on platelet reactivity to arterial subendothelium during blood flow","volume":"94","author":"McGill M","year":"1979","journal-title":"J Lab Clin Med"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1994.34694295074.x"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1053\/tm.rv.2001.22617"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13371"},{"key":"e_1_2_9_84_1","first-page":"e53823","article-title":"Microfluidic flow chambers using reconstituted blood to model hemostasis and platelet transfusion in vitro","volume":"109","author":"Van Aelst B","year":"2016","journal-title":"J Vis Exp"},{"key":"e_1_2_9_85_1","first-page":"1104","article-title":"Evaluation of the hemostatic function of stored platelet concentrates using the platelet function analyzer (PFA\u2010100)","volume":"84","author":"Borzini P","year":"1999","journal-title":"Haematologica"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2007.00938.x"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13760"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12534"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000082"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14780"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V126.23.772.772"},{"key":"e_1_2_9_92_1","unstructured":"Summary of safety and effectiveness data (SSED) for pathogen reduction system for platelets. 2014. Available from:http:\/\/www.fda.gov\/downloads\/BiologicsBloodVaccines\/BloodBloodProducts\/ApprovedProducts\/PremarketApprovalsPMAs\/UCM431243.pdf."},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02694.x"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14042"},{"key":"e_1_2_9_95_1","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1182\/blood.V130.Suppl_1.704.704","article-title":"Hemostatic efficacy of pathogen\u2010inactivated buffy coat\u2010derived platelet concentrates in hemato\u2010oncological patients: outcomes of the prepares trial","volume":"130","author":"Van Der Meer PF","year":"2017","journal-title":"Blood"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1991.31491213293.x"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.1997.7310036.x"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-7963(94)70096-1"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1996.36696269513.x"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.15559","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.15559","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.15559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T18:39:15Z","timestamp":1694198355000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.15559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,23]]},"references-count":98,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/trf.15559"],"URL":"https:\/\/doi.org\/10.1111\/trf.15559","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,23]]},"assertion":[{"value":"2019-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}