{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T19:47:10Z","timestamp":1778701630500,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Turbidity tests are commonly used for screening blood units for the presence of sickle cell trait (SCT) before transfusion to specific patient populations, based on recommendations of the AABB. In this pilot study, we evaluate a new method for screening blood donors and blood units for the presence of sickle hemoglobin.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>This study was based at King Abdulaziz University Hospital in Jeddah, Saudi Arabia. Study participants were approached consecutively between July 24, 2016, and August 8, 2016. Blood donors, control individuals, and known patients with sickle cell disease (SCD) were tested using both a point\u2010of\u2010care testing technology (Sickle SCAN, Biomedomics, Inc.) and hemoglobin capillary electrophoresis (HEP). Corresponding blood units were also tested using Sickle SCAN.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 200 donors, 13 blood units, and 57 patients and controls were included. Sensitivity and specificity of Sickle SCAN for detection of SCT and SCD was 100%, when compared to HEP as the gold standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Sickle SCAN is a rapid test that shows high sensitivity and specificity for identification of hemoglobin S among blood donors and when used for testing blood units.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15586","type":"journal-article","created":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T11:06:36Z","timestamp":1583406396000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of a point\u2010of\u2010care method for screening blood donors for sickle cell status"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3272-2393","authenticated-orcid":false,"given":"Maha","family":"Badawi","sequence":"first","affiliation":[{"name":"Department of Hematology King Abdulaziz University  Jeddah Saudi Arabia"},{"name":"King Abdulaziz University Hospital  Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Garoot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mofida","family":"Tahlawi","sequence":"additional","affiliation":[{"name":"King Abdulaziz University Hospital  Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3804-5434","authenticated-orcid":false,"given":"Salwa","family":"Hindawi","sequence":"additional","affiliation":[{"name":"Department of Hematology King Abdulaziz University  Jeddah Saudi Arabia"},{"name":"King Abdulaziz University Hospital  Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soheir","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Hematology King Abdulaziz University  Jeddah Saudi Arabia"},{"name":"Department of Medicine Duke University  Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30193-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006223422502"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70204-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-09-551564"},{"key":"e_1_2_8_6_1","volume-title":"Technical manual","author":"Fung M","year":"2017"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14233"},{"issue":"1","key":"e_1_2_8_8_1","first-page":"s193","article-title":"Assessment of leucoreduction of sickle cell trait blood: quality of the filtered product","volume":"12","author":"Amar KO","year":"2014","journal-title":"Blood Transfus"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.08.006"},{"key":"e_1_2_8_10_1","first-page":"137","article-title":"Do we need to test blood donors for sickle cell anaemia?","volume":"8","author":"Piccin A","year":"2010","journal-title":"Blood Transfus"},{"key":"e_1_2_8_11_1","first-page":"199","article-title":"An unusual case of a spurious, transfusion\u2010acquired haemoglobin S","volume":"8","author":"Lippi G","year":"2010","journal-title":"Blood Transfus"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1373\/jalm.2016.022608"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e318065a9e8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.2003.354"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-015-1583-0"},{"key":"e_1_2_8_16_1","unstructured":"Sickle SCAN. sicklescan. 2019. [cited 2019 Aug 10]. Available from:https:\/\/www.sicklescan.com\/."},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2016.5.15084"},{"issue":"5","key":"e_1_2_8_18_1","first-page":"771","article-title":"Why do Saudi women refrain donating their blood?\u2010 a study on the attitude, belief and motivation of Saudi female university students towards blood donation","volume":"62","author":"Al\u2010Johar A","year":"2016","journal-title":"Clin Lab"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0473-6"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3lc41302k"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.1308.1308"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2017.08.010"},{"key":"e_1_2_8_23_1","unstructured":"Streckinc-wpengine.netdna-ssl.com.2019. [cited 2019 Aug 10]. Available from:https:\/\/streckinc-wpengine.netdna-ssl.com\/wp-content\/uploads\/2017\/01\/02_Paper_SICKLEDEX_-_Screening_Test_Guidelines.pdf."},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-3182-8"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12878-018-0120-5"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.15586","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.15586","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.15586","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.15586","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T01:10:46Z","timestamp":1694049046000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.15586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":24,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/trf.15586"],"URL":"https:\/\/doi.org\/10.1111\/trf.15586","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"2019-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}