{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T18:49:04Z","timestamp":1781203744317,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dalian Science Program Guiding Project","award":["[2013] No. 50"],"award-info":[{"award-number":["[2013] No. 50"]}]},{"name":"Special fund of Development Center for Medical Science & Technology of Chinese Ministry of Health","award":["[2012] No.12\/28-8-3"],"award-info":[{"award-number":["[2012] No.12\/28-8-3"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Chinese blood donors with unconfirmed serological and\/or molecular screening results are deferred permanently. This study investigated the implementation and performance of a follow\u2010up program aiming to improve the notification and management of deferred donors in Dalian, China.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>From January 2013 to February 2018, 411,216 donations were tested for HBsAg, anti\u2010HCV, anti\u2010HIV\/HIV antigen, and antibodies to Treponema pallidum. HBV, HCV, and HIV nucleic acid testing (NAT) was performed in mini\u2010pools of six or in individual donations (IDs). Reactive donations were evaluated further with alternative serological assays and ID\u2010NAT re\u2010testing. A follow\u2010up procedure was developed to evaluate a subset of deferred donors that were either potential NAT yield cases, serology non\u2010reactive and NAT non\u2010repeated reactive (NRR), or serology NRR irrespective of NAT result.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Serological and molecular routine, plus supplemental testing, identified HBV, HCV, HIV, and TP in 503 (0.12%), 392 (0.09%), 156 (0.04%), and 2041 (0.49%) donations, respectively. Overall, 683 of 4156 (16.4%) eligible donors and 205 donors deferred prior 2013 participated in the program. They included 664 serology NRR and 224 NAT yield cases, and 58.8% repeat donors. All markers combined, follow\u2010up documented false reactivity, primary acute infections, and OBI in 61.9% (550\/888), 3.3% (29\/888), and 12.8% (114\/888) of these donors, respectively. Isolated anti\u2010HBc or anti\u2010HBs reactivity was observed in 22% of cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Follow\u2010up testing refined infection status in 78.0% (693\/888) of deferred donors with unconfirmed screening results. This high false\u2010positive rate encouraged to reevaluate the current screening strategies and to consider donor reentry.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15656","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T13:00:36Z","timestamp":1578402036000},"page":"334-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Follow\u2010up program for blood donors with unconfirmed screening results reveals a high false\u2010positive rate in Dalian, China"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2212-9297","authenticated-orcid":false,"given":"Xuelian","family":"Deng","sequence":"first","affiliation":[{"name":"Dalian Blood Center  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zang","sequence":"additional","affiliation":[{"name":"Dalian Blood Center  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmei","family":"Wang","sequence":"additional","affiliation":[{"name":"Dalian Blood Center  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"Dalian Blood Center  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangdi","family":"Liu","sequence":"additional","affiliation":[{"name":"Dalian Blood Center  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Gao","sequence":"additional","affiliation":[{"name":"Dalian Blood Center  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Xu","sequence":"additional","affiliation":[{"name":"Dalian Blood Center  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Dalian Blood Center  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Fan","sequence":"additional","affiliation":[{"name":"Dalian Blood Center  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7738-5373","authenticated-orcid":false,"given":"Daniel","family":"Candotti","sequence":"additional","affiliation":[{"name":"Department of Blood Transmitted Agents National Institute of Blood Transfusion  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Liang","sequence":"additional","affiliation":[{"name":"Dalian Blood Center  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00352-18"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12675"},{"key":"e_1_2_7_4_1","first-page":"1241","article-title":"Blood screening and blood donor deferral in 357 Chinese blood banks","volume":"25","author":"Deng X","year":"2012","journal-title":"Chinese J Blood Transfus"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01480.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13381"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01844.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12644"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12553"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13282"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01973.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.03.034"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.00611.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00029"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13135"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4215-9"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12190"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12556"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13819"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-316490"},{"issue":"1","key":"e_1_2_7_21_1","first-page":"193","article-title":"Development of alternative procedures for HBV DNA confirmation in blood donors with non\u2010 reproducible reactive nucleic acid testing","volume":"113","author":"Deng X","year":"2018","journal-title":"Vox Sang"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.15656","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.15656","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.15656","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.15656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T03:12:28Z","timestamp":1693883548000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.15656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,7]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/trf.15656"],"URL":"https:\/\/doi.org\/10.1111\/trf.15656","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,7]]},"assertion":[{"value":"2019-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}