{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:38:45Z","timestamp":1786466325541,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T00:00:00Z","timestamp":1579651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Cross\u2010matched platelet (cross\u2010matched PLT) transfusion is effective for immune\u2010mediated platelet transfusion refractoriness (PTR), but is more costly and time\u2010consuming for physical cross\u2010match than using standard PLT units. Recent studies have reported the utility of human leucocyte antigens (HLA) virtual cross\u2010matched PLT (HLA\u2010matched PLT) that is defined as HLA\u2010A\/B matched or no antibody against donor\u2010specific antigen. Here, we evaluated the effect of HLA\u2010matched PLTs for PTR in post hematopoietic stem cell transplant (HSCT) recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>Our study included a total of 241 PLTs in 16 patients who underwent HSCT at Okayama University Hospital between 2010 and 2017, receiving either HLA\u2010matched or cross\u2010matched PLTs. We calculated the 24\u2010hour corrected count increments (CCI\u201024) to evaluate the effect of PLTs. A CCI\u201024 \u2265\u20094500 was considered to be a successful transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>We analyzed 139 cross\u2010matched PLTs and 102 HLA\u2010matched PLTs. In the immune\u2010mediated PTR, the rate of successful transfusion was 60.5% for cross\u2010matched PLT and 63.4% for HLA\u2010matched PLT (p = 0.825). On the other hand, the median CCI\u201024 for cross\u2010matched PLT transfusions and HLA\u2010matched PLT transfusions were 1856 and 5824 (p\u2009&lt;\u20090.001), with a success rate of 28.1 and 54.1% in cases with non\u2010immune\u2010mediated PTR, respectively (p = 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The effectiveness of HLA\u2010matched PLT is not inferior to cross\u2010matched PLT. This result indicates that physical cross\u2010match can be omitted in post HSCT PTR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15664","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T04:59:50Z","timestamp":1579755590000},"page":"473-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Efficacy of HLA virtual cross\u2010matched platelet transfusions for platelet transfusion refractoriness in hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3484-0265","authenticated-orcid":false,"given":"Keisuke","family":"Seike","sequence":"first","affiliation":[{"name":"Division of Transfusion Okayama University Hospital  Okayama Japan"},{"name":"Department of Hematology and Oncology Okayama University Hospital  Okayama 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