{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:49:07Z","timestamp":1790419747661,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T00:00:00Z","timestamp":1581638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Commonwealth Transfusion Foundation","award":["BCW 01\/16"],"award-info":[{"award-number":["BCW 01\/16"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The clinical and laboratory features of hemolytic disease of the newborn can be challenging to diagnose during pregnancy in the apparent absence of a blood group antibody. Low\u2010frequency antibodies go undetected due to the lack of appropriate antigen\u2010positive reagent red blood cells (RBCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>CASE REPORT<\/jats:title><jats:p>A pregnant woman of Southeast Asian descent was referred to a maternal\u2010fetal medicine outpatient clinic due to a complicated obstetric history and a negative antibody screen. This initial visit at 29\u2009weeks and 0\u2009days\u2019 gestational age (GA) was unremarkable. A hydropic infant, born at 29\u2009weeks and 5\u2009days\u2019 GA, succumbed on the seventh day of life. Comprehensive laboratory testing was performed after birth. The hospital blood bank performed a maternal antibody identification. Direct antiglobulin test was performed on the cord blood. A reference laboratory confirmed an anti\u2010Mi<jats:sup>a<\/jats:sup>, performed paternal Mi<jats:sup>a<\/jats:sup> phenotyping, and identified a hybrid glycophorin B\u2010A\u2010B <jats:italic>GP*Mur<\/jats:italic> allele.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Maternal alloimmunization to low\u2010frequency antigens remains a challenge. Southeast Asians make up a significant percentage in some US locations. Worldwide reports on the frequency of maternal alloimmunization of the MNS system can be used to guide the use of specific reagent RBCs for testing. Such strategies rely on the identification of blood donor units for reagent manufacture and use in perinatal antibody screens.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The incidence of Mi<jats:sup>a<\/jats:sup> and related antibodies is significant among Southeast Asians. In North America, prenatal antibody screening cells are not routinely chosen to match this population. The clinical and societal implications are discussed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15709","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T04:40:20Z","timestamp":1581655220000},"page":"870-874","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Fetal inheritance of <scp><i>GP*Mur<\/i><\/scp> causing severe HDFN in an unrecognized case of maternal alloimmunization"],"prefix":"10.1111","volume":"60","author":[{"given":"Rose A.","family":"Mallari","sequence":"first","affiliation":[{"name":"Pathology &amp; Laboratory Medicine O\u02bcConnor Hospital\/A Community Hospital of County of Santa Clara Heath System  San Jose California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada","family":"Chan","sequence":"additional","affiliation":[{"name":"Pathology &amp; Laboratory Medicine O\u02bcConnor Hospital\/A Community Hospital of County of Santa Clara Heath System  San Jose California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Powers","sequence":"additional","affiliation":[{"name":"Pediatrix Medical Group of San Jose  California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Pandipati","sequence":"additional","affiliation":[{"name":"Obstetrix Medical Group of San Jose  California (Mednax)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Bensing","sequence":"additional","affiliation":[{"name":"Immunohematology Reference Laboratory  Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Biese","sequence":"additional","affiliation":[{"name":"Immunohematology Reference Laboratory  Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8727-1679","authenticated-orcid":false,"given":"Gregory A.","family":"Denomme","sequence":"additional","affiliation":[{"name":"Immunohematology Reference Laboratory  Milwaukee Wisconsin"},{"name":"Versiti Blood Research Institute  Wauwatosa Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2018.07.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002528"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.21307\/immunohematology-2019-706"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000164060.89842.a9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767050903366085"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14538"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1886"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12172"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1987.tb04900.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1994.tb01262.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1994.34494233585.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.1996.tb00731.x"},{"key":"e_1_2_6_14_1","first-page":"95","article-title":"The prevalence of GP Mur and anti\u2010\"Mia\" in a tertiary hospital in Peninsula Malaysia","volume":"24","author":"Prathiba R","year":"2002","journal-title":"Malays J Pathol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.2002.00394.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2004.00555.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2007.00747.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-012-0155-x"},{"key":"e_1_2_6_19_1","article-title":"Fetal inheritance of GP.Mur causing hydrops due to Miltenberger antibodies","volume":"56","author":"Mallari R","year":"2016","journal-title":"Transfusion"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13552"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12357"},{"key":"e_1_2_6_22_1","first-page":"178A","article-title":"Occult hemolytic anemia due to anti\u2010Mur in a patient receiving blood from a region with a prominent Asian donor population","volume":"57","author":"Oak J","year":"2017","journal-title":"Transfusion"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13151"},{"key":"e_1_2_6_24_1","unstructured":"HoeffelEMRS;Myoung O. 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