{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:20:00Z","timestamp":1773408000367,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T00:00:00Z","timestamp":1587513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Laboratory Medicine and Pathology, Haukeland University Hospital, Bergen, Norway"},{"name":"Norwegian Armed Forces Joint Medical Services"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Increasing numbers of emergency medical service agencies and hospitals are developing the capability to administer blood products to patients with hemorrhagic shock. Cold\u2010stored whole blood (WB) is the only single product available to prehospital providers who aim to deliver a balanced resuscitation strategy. However, there are no data on the safety and in vitro characteristics of prehospital stored WB. This study aimed to describe the effects on in vitro quality of storing WB at remote helicopter bases in thermal insulating containers.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>We conducted a two\u2010armed single\u2010center study. Twenty units (test) were stored in airtight thermal insulating containers, and 20\u2009units (controls) were stored according to routine procedures in the Haukeland University Hospital Blood Bank. Storage conditions were continuously monitored during emergency medical services missions and throughout remote and blood bank storage. Hematologic and metabolic variables, viscoelastic properties, and platelet (PLT) aggregation were measured on Days 1, 8, 14, and 21.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Storage conditions complied with the EU guidelines throughout remote and in\u2010hospital storage for 21\u2009days. There were no significant differences in PLT aggregation, viscoelastic properties, and hematology variables between the two groups. Minor significantly lower pH, glucose, and base excess and higher lactate were observed after storage in airtight containers.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Forward cold storage of WB is safe and complies with EU standards. No difference is observed in hemostatic properties. Minor differences in metabolic variables may be related to the anaerobic conditions within the thermal box.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15802","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T10:07:32Z","timestamp":1587550052000},"page":"1544-1551","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Cold\u2010stored whole blood in a Norwegian emergency helicopter service: an observational study on storage conditions and product quality"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2311-0347","authenticated-orcid":false,"given":"Christopher","family":"Bjerkvig","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Haukeland University Hospital  Bergen Norway"},{"name":"Norwegian Naval Special Operations Commando, Norwegian Armed Forces  Bergen Norway"},{"name":"Institute of Clinical Sciences, University of Bergen  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5501-5486","authenticated-orcid":false,"given":"Joar","family":"Sivertsen","sequence":"additional","affiliation":[{"name":"Department of Immunology and Transfusion Medicine Haukeland University Hospital  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4750-0681","authenticated-orcid":false,"given":"Hanne","family":"Braathen","sequence":"additional","affiliation":[{"name":"Department of Immunology and Transfusion Medicine Haukeland University Hospital  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6798-1630","authenticated-orcid":false,"given":"Turid Helen Felli","family":"Lunde","sequence":"additional","affiliation":[{"name":"Department of Immunology and Transfusion Medicine Haukeland University Hospital  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3168-3786","authenticated-orcid":false,"given":"Geir","family":"Strandenes","sequence":"additional","affiliation":[{"name":"Department of Immunology and Transfusion Medicine Haukeland University Hospital  Bergen Norway"},{"name":"Department of War Surgery and Emergency Medicine Norwegian Armed Forces Medical Services  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Assmus","sequence":"additional","affiliation":[{"name":"Department of Research and Development Haukeland University Hospital  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tor","family":"Hervig","sequence":"additional","affiliation":[{"name":"Institute of Clinical Sciences, University of Bergen  Bergen Norway"},{"name":"Department of Immunology and Transfusion Medicine Haukeland University Hospital  Bergen 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Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torunn Oveland","family":"Apelseth","sequence":"additional","affiliation":[{"name":"Department of Immunology and Transfusion Medicine Haukeland University Hospital  Bergen Norway"},{"name":"Department of Clinical Biochemistry and Pharmacology Haukeland University Hospital  Bergen 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