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This review summarizes data describing the inactivation efficacy of amotosalen\/UVA\u2010PRT for a broad spectrum of viruses and parasites.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Twenty\u2010five enveloped viruses, six nonenveloped viruses (NEVs), and four parasites species were evaluated for sensitivity to amotosalen\/UVA\u2010PRT. Pathogens were spiked into plasma and PC at high titers. Samples were collected before and after PRT and assessed for infectivity with cell cultures or animal models. Log reduction factors (LRFs) were defined as the difference in infectious titers before and after amotosalen\/UV\u2010PRT.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>LRFs of \u22654.0 log were reported for 19 pathogens in plasma (range, \u22654.0 to \u22657.6), 28 pathogens in PC in platelet additive solution (PC\u2010PAS; \u22654.1\u2010\u22657.8), and 14 pathogens in PC in 100% plasma (PC\u2010100%; (\u22654.3\u2010&gt;8.4). Twenty\u2010five enveloped viruses and two NEVs were sensitive to amotosalen\/UV\u2010PRT; LRF ranged from &gt;2.9 to \u22657.6 in plasma, 2.4 or greater to greater than 6.9 in PC\u2010PAS and &gt;3.5 to &gt;6.5 in PC\u2010100%. Infectious titers for four parasites were reduced by &gt;4.0 log in all PC and plasma (\u22654.9 to &gt;8.4).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Amotosalen\/UVA\u2010PRT demonstrated effective infectious titer reduction for a broad spectrum of viruses and parasites. This confirms the capacity of this system to reduce the risk of viral and parasitic transfusion\u2010transmitted infections by plasma and PCs in various geographies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15807","type":"journal-article","created":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T03:48:16Z","timestamp":1587786496000},"page":"1319-1331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Inactivation of a broad spectrum of viruses and parasites by photochemical treatment of plasma and platelets using amotosalen and ultraviolet A light"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4213-5013","authenticated-orcid":false,"given":"Marion C.","family":"Lanteri","sequence":"first","affiliation":[{"name":"Department of Scientific Affairs Cerus Corporation  Concord California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia","family":"Santa\u2010Maria","sequence":"additional","affiliation":[{"name":"Department of Microbiology Cerus Corporation  Concord California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Laughhunn","sequence":"additional","affiliation":[{"name":"Department of Microbiology Cerus Corporation  Concord California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette A.","family":"Girard","sequence":"additional","affiliation":[{"name":"Department of Microbiology Cerus Corporation  Concord California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Picard\u2010Maureau","sequence":"additional","affiliation":[{"name":"Department of Scientific Affairs Cerus Europe BV  Amersfoort The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Marc","family":"Payrat","sequence":"additional","affiliation":[{"name":"Department of Scientific Affairs Cerus Europe BV  Amersfoort The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Irsch","sequence":"additional","affiliation":[{"name":"Department of Scientific Affairs Cerus Europe BV  Amersfoort The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5132-2558","authenticated-orcid":false,"given":"Adonis","family":"Stassinopoulos","sequence":"additional","affiliation":[{"name":"Department of Scientific Affairs Cerus Corporation  Concord California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bringmann","sequence":"additional","affiliation":[{"name":"Department of Microbiology Cerus Corporation  Concord California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biologicals.2009.01.006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-833996"},{"key":"e_1_2_8_4_1","unstructured":"US Department of Health and Human Services. 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