{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T21:17:15Z","timestamp":1773091035407,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T00:00:00Z","timestamp":1587686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013995","name":"Sanofi Genzyme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Autologous stem cell transplantation is an established treatment option for patients with multiple myeloma (MM) or non\u2010Hodgkin\u02bcs lymphoma (NHL).<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>In this prospective multicenter study, 147 patients with MM were compared with 136 patients with NHL regarding the mobilization and apheresis of blood CD34+ cells, cellular composition of infused blood grafts, posttransplant recovery, and outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Multiple myeloma patients mobilized CD34+ cells more effectively (6.3\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\/kg vs. 3.9\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\/kg, p\u2009=\u20090.001). The proportion of poor mobilizers (peak blood CD34+ cell count &lt;20\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\/L) was higher in NHL patients (15% vs. 3%, p\u2009&lt;\u20090.001). Plerixafor was added to rescue the mobilization failure in 17\u2009MM patients (12%) and in 35 NHL patients (26%; p\u2009=\u20090.002). The infused grafts contained more natural killer (NK) and CD19+ cells in MM patients. Blood platelet and NK\u2010cell counts were higher in MM patients posttransplant. Early treatment\u2010related mortality was low in both groups, but NHL patients had a higher late (&gt;100\u2009days) nonrelapse mortality (NRM; 6% vs. 0%, p\u2009=\u20090.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Non\u2010Hodgkin\u02bcs lymphoma and MM patients differ in terms of mobilization of CD34+ cells, graft cellular composition, and posttransplant recovery. Thus, the optimal graft characteristics may also be different.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.15820","type":"journal-article","created":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T03:46:12Z","timestamp":1587786372000},"page":"1519-1528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["CD34+ cell mobilization, blood graft composition, and posttransplant recovery in myeloma patients compared to non\u2010Hodgkin\u02bcs lymphoma patients: results of the prospective multicenter GOA study"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3693-2956","authenticated-orcid":false,"given":"Antti","family":"Turunen","sequence":"first","affiliation":[{"name":"Department of Medicine Kuopio University Hospital  Kuopio Finland"},{"name":"Institute of Clinical Medicine University of Eastern Finland  Kuopio 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