{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:05:55Z","timestamp":1787169955687,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Asymptomatic severe iron deficiency anemia is a common finding in subjects admitted to the outpatient anemia clinic. Although the condition can be easily be reversed with intravenous iron (IVI) therapy and several guidelines have suggested a restrictive threshold for using transfusion in hemodynamically stable patients, transfusion is often the rule in clinical practice. This study describes clinical practice results of IVI therapy without transfusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY DESIGN AND METHODS<\/jats:title>\n                    <jats:p>In this multicenter retrospective observational study, data of severely anemic outpatients treated only with high\u2010dose IVI with ferric carboxymaltose were collected. Inclusion criteria were hemoglobin (Hb) level of less than 7.0 g\/dL and ferritin level of less than 30\u2009ng\/mL or mean corpuscular volume of less than 75\u2009fL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Overall, 303 patients referred to the anemia clinic mainly from primary health care centers (46.2%) or the emergency department (28.7%) met the inclusion criteria. Median (interquartile range [IQR]) age was 47 (37\u201062) years and 84.5% were female. The median (IQR) Hb concentration at first visit was 6.5 (6.1\u20106.8) g\/dL, 64 patients (21.1%) presented with a Hb level of less than 6.0 g\/dL at diagnosis, and 11 of them (3.6%) had extreme anemia (Hb \u2264\u20095 g\/dL). Gynecologic and gastroenteric bleeding were the main cause. After a mean IV administration of 1500\u2009mg of iron, the Hb increased by a median of 5.7 g\/dL. Thirteen patients experienced only mild side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>In chronic very severe sideropenic anemias, third\u2010generation IVI is effective and safe for quick correction and avoidance of red blood cell transfusion. These results suggest that more specific guidelines for this clinical setting are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.15870","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T06:57:00Z","timestamp":1593413820000},"page":"1443-1449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Efficacy and safety of high\u2010dose intravenous iron as the first\u2010choice therapy in outpatients with severe iron deficiency anemia"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1049-4027","authenticated-orcid":false,"given":"Carlos","family":"Jeric\u00f3","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hospital Sant Joan Desp\u00ed\u2010Mois\u00e9s Broggi, Consorci Sanitari Integral  Barcelona Spain"},{"name":"Department of Medicine Autonomous University of Madrid  Madrid Spain"},{"name":"PBM Group Hospital La Paz Institute for Health Research (IdiPAZ)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9486-9740","authenticated-orcid":false,"given":"Ivo","family":"Beverina","sequence":"additional","affiliation":[{"name":"Blood Transfusion Centre Legnano General Hospital  Legnano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2226-4392","authenticated-orcid":false,"given":"Manuel","family":"Quintana\u2010Diaz","sequence":"additional","affiliation":[{"name":"Department of Medicine Autonomous University of Madrid  Madrid Spain"},{"name":"PBM Group Hospital La Paz Institute for Health Research (IdiPAZ)  Madrid Spain"},{"name":"Intensive Care Unit University Hospital La Paz  Madrid 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5129-8597","authenticated-orcid":false,"given":"Valle","family":"Recasens","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Universitario Miguel Servet  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9163-1515","authenticated-orcid":false,"given":"Bruno","family":"Brando","sequence":"additional","affiliation":[{"name":"Blood Transfusion Centre Legnano General Hospital  Legnano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7662-6286","authenticated-orcid":false,"given":"Jos\u00e9 Antonio","family":"Garcia\u2010Erce","sequence":"additional","affiliation":[{"name":"PBM Group Hospital La Paz Institute for Health Research (IdiPAZ)  Madrid Spain"},{"name":"REDGERM Grupo Espa\u00f1ol de Rehabilitaci\u00f3n Multimodal  Zaragoza Spain"},{"name":"Blood and Tissue Bank of Navarra Servicio Navarro de Salud\u2010Osasunbidea  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-508325"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2019.07.006"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/cem.2016.388"},{"key":"e_1_2_7_6_1","first-page":"199","article-title":"Appropriate use of red blood cell transfusion in emergency departments: a study in five emergency departments","volume":"15","author":"Quintana\u2010D\u00edaz M","year":"2017","journal-title":"Blood Transfus"},{"key":"e_1_2_7_7_1","article-title":"Transfusions in the emergency department: more than a blood transfusion","author":"Quintana\u2010D\u00edaz 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